窄谱中波紫外线联合罗红霉素治疗难治性玫瑰糠疹疗效观察

Clinical Observation on Narrow-band Ultraviolet B Combined with Roxithromycin in the Treatment of Refractory Pityriasis Rosea

目的观察窄谱中波紫外线联合罗红霉素治疗难治性玫瑰糠疹的临床疗效及安全性。方法将72例患者随机分为两组,治疗组40例,给予罗红霉素缓释片0.3 g,口服,每日1次,窄谱中波紫外线照射,隔日1次,共20 d,盐酸西替利嗪片10 mg,口服,每日1次,连续20 d;对照组32例,只给予西替利嗪片10 mg,服用方法和时间同治疗组。两组均局部外用炉甘石洗剂。结果治疗组有效率为89.4%,对照组有效率为27.3%,治疗组明显优于对照组,两组间差异有统计学意义(P<0.01)。结论窄谱中波紫外线联合罗红霉素治疗玫瑰糠疹疗效好,安全性高,值得临床应用。

[Objective]To observe the clinical efficacy and safety of narrow-band ultraviolet B combined with roxithromycin in the treatment of refractory pityriasis rosea. [Methods]72 patients with pityriasis rosea were randomly divided into two groups.The treatment group（40 cases） was given orally-administered sustained-release roxithromycin tablets 0.3g once daily,narrow-band ultraviolet B tertian irradiation for 20 days,orally-administered cetirizine hydrochloride tablets 10 mg once daily for 20 days.The control group was only given orally-administered cetirizine hydrochloride tablets 10 mg once daily.Both groups received topical application of calamine lotion. [Results]The effective rate of the treatment group（89.4%） was higher than that of the control group（27.3%） significantly（P0.01）. [Conclusion]Narrow-band ultraviolet B combined with roxithromycin is effective and safe in the treatment of pityriasis rosea,which is worthy of clinical application.