灯盏花乙素在模拟人体胃肠环境中的稳定性研究

Study the Stability of Scutellarin on Simulated Gastric Fluid and Simulated Intestinal Fluid

目的:以《中国药典》现行版中的人工胃液和人工肠液模拟人体胃肠环境,对灯盏花乙素在其中的稳定性进行研究。方法:将灯盏花乙素放入模拟人工胃液和人工肠液条件,HPLC和LC—MS鉴定结果。结果:灯盏花乙素在人工胃液中从0.5～2.5h出现降解产物,经LC-MS鉴定降解产物为灯盏花乙素苷元,而灯盏花乙素在人工肠液中沒有出现降解产物。结论:灯盏花乙素在人工胃液中不稳定而在人工肠液中较为稳定。

Objective： We used the methods in CHP to analog the stomach and intestine environment to study the stability of scutellarin in simulated gastric fluid and simulated intestinal fluid. Methods： Put scutellarin into artificial stomach and intestines of the artificial, With HPLC and LC - MS results. Results： Scutellarin ap- pearing degradation products which has been identified to be scutellarein in 0. 5h -2. 5h. But in simulated intestinal liquid don＇t have an object becomes degradation. Conclusions： Seutellarin was not stable in simulated gastric liquid, but it was stable in simulated intestinal liquid.