丽水地区妇女感染人乳头瘤病毒基因型模式

Genotypes of human papillomavirus infection in women in Lishui area

目的:了解丽水地区妇女人乳头瘤病毒(HPV)基因型在宫颈疾病中的感染状况及其分布特点。方法:以该地区2008年9月19日到2011年3月15日期间2 638例妇科患者为研究对象,运用HybriX ax医用核酸分子快速杂交系统进行21种HPV(6、11、16、18、31、33、35、39、42、43、44、45、51、52、53、56、58、59、66、68、CP 8304)基因型的分型检测,分析常见感染亚型和分布特点。结果:研究人群HPV总阳性率为50.87%,常见的10种高危型为HPV 16、52、58、33、31、53、68、CP 8304、18、39型;常见的2种低危型为HPV 11、6型。多重感染的比例为32.41%,其中以二重感染最多见。结论:该地区HPV感染率和多重感染比例均较高,常见感染亚型总体符合亚洲人群的分布规律,又有独特的区域分布特点,值得重视。

Objective To investigate the infection of Human Papillomavirus（HPV） genotype in cervical diseases and their distribution characteristic in women in Llishui area.Methods The clinical common genotype and the characteristic distribution of HPV was analyzed.A total of 2638 women patients in the locality during 19,Sep.2008 to 15,Mar.2011 were selected for 21 genotypes（6,11,16,18,31,33,35,39,42,43,44,45,51,52,53,56,58,59,66,68,CP8304）HPV detecting with HybriMax.Results The total positive rate of HPV infection was 50.87%.The 10 most common high-risk genotypes were HPV16,52,58,33,31,53,68,CP8304,18,39.The 2 most common low-risk genotypes were HPV11,6.The total multiple infection rate was 32.41 % and two types co-infection were the most common situation.Conclusion The prevalence of HPV infection and multiple infection are common.The infection genotypes are accordant to those of Asia,yet still have its own characters.