小剂量激素补充治疗对绝经早期妇女乳腺作用的研究

Study on the effect of low-dose hormone supplement treatment on mammary gland of early menopausal women

目的:研究绝经早期妇女小剂量激素补充治疗(HT)对乳腺的作用。方法:按自愿、随机的原则将206例绝经早期妇女分为治疗组和对照组,每组各103例,治疗1年,每3个月随访复诊1次,记录患者乳腺疼痛、坠胀、溢液等情况,观察乳腺改变。结果:6个月内治疗组乳腺疼痛、坠胀发生率明显高于对照组(P<0.001),6个月后两组比较差异无统计学意义(P>0.05),乳头溢液发生率明显高于对照组(P<0.01);治疗组乳腺小叶增生症发生率明显高于对照组(P<0.001);观察1年两组均未发生乳腺癌。结论:小剂量激素补充治疗对绝经早期妇女乳腺作用较明显,乳腺小叶增生症发生率增高,应加强对乳腺的监测,定期进行复查。

Objective：To study the effect of low-dose hormone supplement treatment on mammary gland of early menopausal women.Methods：206 early menopausal women were divided into treatment group and control group on the principle of voluntariness and random,103 cases in each group,the cases were treated for one year and followed up every three months,the situations including ache,fall-swell of mammary gland and nipple discharge were recorded,the change of mammary gland was observed.Results：The incidences of ache and fall-swell of mammary gland within 6 months in treatment group were significantly higher than those in control group（P0.001）,but there was no significant difference between the two groups after 6 months（P0.05）,the incidence of nipple discharge in treatment group was significantly higher than that in control group（P0.01）.The incidence of breast lobular hyperplasia in treatment group was significantly higher than that in control group（P0.001）;no breast cancer occurred in the two group based on follow-up for one year.Conclusion：The effect of low-dose hormone supplement treatment on mammary gland of early menopausal women is obvious,the therapy increases the incidence of breast lobular hyperplasia,the monitoring of mammary gland should be enhanced,regular follow-up should be carried out.