不良孕产史与染色体异常的关系研究

Study on the relationship between adverse pregnancy history and chromosomal abnormality

目的:统计不良孕产史患者中异常核型的比例,探讨不良孕产史与细胞遗传学的关系。方法:对1 365例具有不良孕产史的患者采用外周血进行淋巴细胞培养,制备染色体标本,G显带核型分析后结合临床资料对其进行染色体异常与男女发生的比例及不良孕产次数与染色体异常的关系进行统计学分析。结果:1 365例完成核型分析的检查者中,染色体异常20例,异常检出率1.47%。主要以男性染色体异常为主,男女性别与染色体异常检出率的差异无统计学意义,不良孕产史次数与染色体异常检出率差异有统计学意义。结论:染色体异常是导致不良孕产史等疾病的重要原因之一,进行染色体检查,可为临床诊断和治疗提供科学依据。

Objective：To analyze the proportion of abnormal karyotypes in the patients with adverse pregnancy history,explore the relationship between adverse pregnancy history and cytogenetics.Methods：The perinatal blood samples were obtained from 1 365 patients with adverse pregnancy history for lymphocyte culture,then chromosomal specimens were prepared,G-banding analysis combined with clinical data were used to statistically analyze the incidence of chromosomal abnormality,the proportions of female cases and male cases,the relationship between adverse pregnancy history and chromosomal abnormality.Results：Among 1 365 cases who had finished karyotype analysis,20 cases were found with chromosomal abnormality,the abnormal detection rate was 1.47%.Male chromosomal abnormality was the major type,there was no significant difference in the abnormal detection rate between female cases and male cases,but there was significant difference in the abnormal detection rate among cases with adverse pregnancy history of different times.Conclusion：Chromosomal abnormality is an important reason of adverse pregnancy history,chromosomal detection can provide a scientific basis for clinical diagnosis and treatment.