摘要
目的:探讨Y染色体无精子因子(AZF)微缺失在习惯性流产夫妇中的发生情况。方法:采用聚合酶链反应技术对7例习惯性流产夫妇中的男性Y染色体上AZF基因(STS)上的3个位点SY157、SY254、SY255及ZFX/ZFY基因进行检测。结果:7例男性中的1例(14.29%)在所检测的3个位点有1处缺失,10例可生育且无流产史的男性未见任何微缺失。结论:习惯性流产夫妇中男性AZF缺失可能是造成习惯性流产的一个原因,两者有一定的相关性。
Objective：To explore the prevalence of Y chromosome azoospermia factor（AZF） microdeletion in the couples with habitual abortion.Methods：PCR technique was used to detect SY157 locus,SY254 locus and SY255 locus in male Y chromosome AZF gene and ZFX/ZFY gene of 7 couples with habitual abortion.Results：Among 7 men,one man（14.29%） was found with one microdeletion of the three sites detected,10 men without the history of abortion had no microdeletion.Conclusion：Among the couples with habitual abortion,male AZF microdeletion is a reason of habitual abortion,there is a certain correlation between AZF microdeletion and habitual abortion.
出处
《中国妇幼保健》
CAS
北大核心
2011年第28期4404-4405,共2页
Maternal and Child Health Care of China
关键词
习惯性流产
无精子因子
微缺失
Habitual abortion
Azoospermia factor
Microdeletion
