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“三阴性”乳腺癌分子靶向治疗的研究进展 被引量:4

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摘要 分子靶向治疗(Molecular targeted therapy)是在细胞分子水平上,针对已经明确的致癌位点(该位点可以是肿瘤细胞内部的一个蛋白分子,也可以是一个基因片段)来设计相应的治疗药物,药物进入人体后会特异性地选择致癌位点相结合并发生作用,通过阻断肿瘤细胞或相关细胞的信号传导,来控制细胞基因表达的改变,从而特异性地抑制或杀死肿瘤细胞。据2008年统计。
出处 《中国妇幼保健》 CAS 北大核心 2011年第30期4787-4789,共3页 Maternal and Child Health Care of China
基金 国家自然科学基金项目〔81060166〕
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同被引文献62

  • 1司徒红林,林毅,陈前军,欧爱华,朱华宇,刘鹏熙,任黎萍.中药癌复康对乳腺癌术后化疗患者生存质量的影响[J].广州中医药大学学报,2005,22(1):26-29. 被引量:18
  • 2刘鹏熙,林毅,陈前军.乳腺癌围手术期中医药参与治疗的若干问题探讨[J].中西医结合学报,2005,3(3):178-180. 被引量:15
  • 3林毅,陈前军,刘鹏熙.乳腺癌分期辨证规范化——一个中医乳房病学与时俱进的重要课题[J].中西医结合学报,2006,4(5):447-450. 被引量:35
  • 4闫成.三阴性乳腺癌的临床研究进展[J].医学信息(下旬刊),2013,26(10):694.
  • 5陈龙邦;刘福坤.循证肿瘤治疗学[M]郑州:郑州大学出版社,2004184.
  • 6中华医学会.临床治疗指南-肿瘤分册[M]北京:人民卫生出版社,2005170.
  • 7Anders CK,Carey LA. Biology,metastatic patterns,and treatment of patients with triple-negative breast cancer[J].Clinical Breast Cancer,2009,(Suppl 2):S73.
  • 8张宇,李积德.三阴性乳腺癌的分子病理学特征及其治疗进展[J].中国保健营养(中旬刊),2012(4):640-641.
  • 9Ma CX,Cai S,Li S,et al.Targeting Chk1 in p53-deficient triplenegative breast cancer is therapeutically beneficial in human-inmouse tumor models[J].J Clin Invest,2012,22(4):1541-1552.
  • 10Seitz S,Buchholz S,Schally AV,et al.Targeting triple-negative breast cancer through the somatostatin receptor with the new cytotoxic somatostatin analogue AN-162[AEZS-124][J].Anticancer Drugs,2013,24(2):150-157.

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