巨噬细胞加帽蛋白与肺癌患者转移预后的关系

Relationship between macrophage-capping protein expression and prognosis of patients with lung cancer metastasis

目的:探讨巨噬细胞加帽蛋白(CapG)在肺癌临床病理特征、癌细胞转移和患者预后中的价值。方法:S-P免疫组化法检测63例有完整资料的肺癌患者癌组织标本及相应癌旁组织CapG蛋白表达,分析CapG蛋白与肺癌患者临床病理特征和转移预后的关系。结果:CapG蛋白肺癌细胞胞浆及胞核阳性表达为33.3%(21/63),并与肺癌组织学类型、肿瘤分化程度、肿瘤大小、临床分期、淋巴结转移及抽烟有关(P<0.05);Kaplan-Meier生存分析显示CapG蛋白阳性患者生存率较阴性患者为低(P<0.05),Cox风险比例模型显示淋巴结转移及CapG蛋白阳性可显著增加肺癌患者的死亡风险(P<0.05)。结论:CapG基因在肺癌发生发展中起重要作用,与肺癌转移及低生存率有关,可作为临床早期发现肺癌转移及预测预后的指标。

Objective：To investigate the expression of macrophage-capping protein（CapG） in lung cancer,and evaluate the value of CapG expression in clinicopathological features,metastasis and survival of lung cancer patients.Methods： SP immunohistochemical method was used to detect the expression of CapG protein in 63 lung carcinoma and 63 matched noncancerous tissues.Then the relationship of CapG protein to clinicopathological features,metastasis and prognosis of the patients were analyzed.Results： The positive rate of CapG protein in lung carcinoma was 33.3%（21/63）,which was significantly associated with histotype,degree of differentiation,size of tumor,lymph node metastasis and smoking（P〈0.05）;Kaplan-Meier survival analysis showed that the survival time of CapG positive patients was shorter than that of CapG negative patients（P〈0.05）;Cox regression analysis revealed that lymph node metastasis and CapG positive expression were the noticeable affective factors on the death of the lung cancer patients after surgery（P〈0.05）.Conclusion： CapG play an important role in the development of lung cancer and was associated with metastasis and low survival rate in patients with lung cancer,which can be used as an early biomarker of lung cancer metastasis and prognostic prediction.