三聚氰胺污染奶粉致双肾结石婴幼儿2年后随访分析

Two Years Follow-up of 50 Young Children with Bilateral Renal Calculus Induced by Melamine Contaminated Milk Powder

目的:探讨三聚氰胺污染奶粉致双肾结石对婴幼儿生长发育的影响。方法:对2008年7～10月治疗的50例三聚氰胺双肾结石患儿(双肾结石组)进行2年后随访。随访包括泌尿系超声检查、肾功能检查、尿常规,同时记录身高、体重、临床症状及并发症情况。选取50例无三聚氰胺污染奶粉喂养史的正常儿童作为对照组,比较两组间的相关参数差异。结果:41例患儿得到成功随访。28例带石出院患儿中21例结石消失,5例变小,1例无明显变化,另1例变大。1 5例出院时仍有双侧或单侧肾积水患儿中9例消失,5例减轻及1例无明显变化。双肾结石组患儿补钙的比例明显低于对照组(P<0.05),身高偏低的比例明显高于对照组(P<0.05),体重差异无统计学意义(P>0.05)。随访时未发现泌尿系占位性病变。结论:三聚氰胺污染奶粉致双肾结石患儿2年后随访显示,泌尿系统发育及生长发育未见明显影响。

Objective： To follow-up the bilateral renal calculus in young children who were fed with melamine contaminating milk powder 2 years ago. Methods： Fifty young children with bilateral renal calculus induced by melamine contaminated milk powder were followed up by urinary ultrasonography,urinalysis and renal function tests. The data of body weight and height,clinical signs, complications were collected. Fifty normal children without the history of consuming melamine contaminated milk powder were collected as controls. Results： Forty-one young chil- dren were successfully followed up. Twenty-eight showed residual stones in the kidney at the time of discharge, 21 disappeared completely,5 dissolved partially,1 increased in size and 1 did not change at the time of follow-up. Of the 15 infants with hydronephrosis at the time of discharge, 1 did not change, 5 decreased in size,and others recov- ered to normal at the time of follow-up. The percentages of under-height infants was significantly higher in the hilateral renal calculus group compared to the controls （P^0.05）. Furthermore,the percentage of infants with calci- um supplementation was significantly lower in the former group （P^0.05）. No urological tumors were detected. Routine blood,renal and bladder function testing as well as urinalysis were normal. Conclusions：At 2-year follow- up,melamine-tainted milk powder induced bilateral urinary stone has not been found to induce a noticeable impact on kidney and body growth.