载脂蛋白A1水平在不同脊髓损伤患者中的差异性研究

Investigation on apolipoprotein A-I levels in spinal cord injury patients

目的:通过对不同脊髓损伤患者血清载脂蛋白A1(ApoA-I)水平回顾性资料的流行病学调查,进行差异比较和相关因素分析,探讨造成这一心血管保护因子差异形成的可能机制和临床意义。方法:对中国康复研究中心2004年1月—2010年12月因脊髓损伤入院进行康复治疗的患者进行入院后ApoA-I水平回顾性调查。结果:女性脊髓损伤患者ApoA-I水平高于男性患者,截瘫患者ApoA-I水平高于四肢瘫患者,男性患者ApoA-I水平还受年龄和病程影响,女性患者ApoA-I水平与年龄和病程不相关。结论:ApoA-I水平在不同脊髓损伤类型患者间存在差异,男女不同性别之间也存在差异,雌激素保护作用和运动能力不同可能是造成差异的主要原因。

Objective：To epidemiologically investigate the retrospective-data-based serum apolipoprotein A-I（ApoA-I） levels in Chinese adults with spinal cord injury（SCI） and compare the differences among different subgroups for exploring the possible mechanism and clinical significance of ApoA-I differences.Method：A total of 2240 SCI patients who admitted into China Rehabilitation Research Center（CRRC） for rehabilitation therapy from Jan 2004—Dec 2010 were investigated.ApoA-I was measured by standard laboratory method.Result：Female SCI patients showed higher ApoA-I levels than male SCI patients,and paraplegic patients showed higher ApoA-I levels than tetraplegic patients.Male SCI patients’ ApoA-I level was correlated positively to age and duration of SCI,but female patients did not.Conclusion：ApoA-I levels were significantly different between paraplegias and tetraplegias,so were between male and female patients.The differences maybe resulted from estrogen protection effect and differences of exercise capacities