红花黄色素可促进人脐静脉内皮细胞的增殖

Hydroxysafflor yellow A promotes the proliferation of human umbilical vein endothelial cells

背景:心血管疾病的发生、发展与内皮细胞增生及凋亡有关。目的:观察红花黄色素对血管内皮细胞模型的保护作用。方法:体外培养人脐静脉内皮细胞,先采用红花黄色素进行干预,随后采用溶血卵磷脂体外诱导建立人脐静脉内皮细胞损伤模型,并设置对照组。结果与结论:与对照组比较,溶血卵磷脂干预的人脐静脉内皮细胞增殖减弱(P<0.05),细胞凋亡增加(P<0.05),一氧化氮浓度降低(P<0.01),而经红花黄色素干预后上述现象均可被逆转(P<0.05)。结果证实,红花黄色素可通过促进内皮细胞增殖,抑制其凋亡并增加一氧化氮浓度对溶血卵磷脂诱导的内皮细胞损伤起保护作用。

BACKGROUND：The occurrence and development of cardiovascular diseases are related to the proliferation and apoptosis of vascular endothelial cells （VECs）. OBJECTIVE：To investigate the protective effects of hydroxysafflor yellow A （HSYA） on human VEC （hVEC） models. METHODS：The hVECs cultured in vitro were interfered with HSYA and then were established into hVEC injury models by in vitro induction of lysophosphatidyl choline. A control group was set. RESULTS AND CONCLUSION：Compared with the control group, hVECs proliferation was significantly decreased （P 0.05）, cell apoptosis was significantly increased （P 0.05） and nitric oxide concentration was significantly decreased （P 0.01） after lysophosphatidyl choline intervention. However, after treatment with HSYA, these symptoms could be reversed （P 0.05）. Results showed that HSYA could promote the proliferation of hVECs, inhibit cell apoptosis, and increase nitric oxide concentration, exhibiting protective effects on lysophosphatidyl choline-induced injury to hVECs.