基底膜蛋白多糖的功能多样:血管发生与软骨形成及软骨骨化

Multi-functional perlecan: angiogenesis, chondrogenesis and chondrosteosis

背景:基底膜蛋白多糖功能多样,在调节血管生物学行为和损伤修复中具有重要作用。目的:探讨基底膜蛋白多糖在组织发育、血管发生、软骨形成中的调节机制。方法:应用计算机检索Sciencedirect和中国生物医学文献数据库(2000-01/2010-12),检索词分别为"perlecan,angiogenesis,cartilage,heparan sulfate,vascular endothelial growthfacto"和"基底膜蛋白多糖,血管,软骨,硫酸乙酰肝素,血管内皮生长因子"。纳入与基底膜蛋白多糖的表达、功能密切相关,同一领域选择近期发表或在权威杂志发表的文章。排除重复性研究或Meta分析类文章。结果与结论:检索到129篇文献,按纳入及排除标准筛选后,共纳入35篇符合标准的文献。经分析得出以下结论:基底膜蛋白多糖在机体发育过程必不可少,其具体作用机制受细胞微环境的影响。基底膜蛋白多糖功能强大,在与生长因子、成形素、基质蛋白交互作用下,可用相同的机制来调节每一个程序。

BACKGROUND：Perlecan functions in a diverse range which ranges from the regulation of cell growth and adhesion to extracellular matrix assembly. We previously identified a central function for perlecan during angiogenic blood vessel development and injury restoration. OBJECTIVE：To explore the mechanism of perlecan in tissue development and organogenesis. METHODS：A computer-based retrieval was performed to search manuscripts published between January 2000 and December 2010 in Sciencedirect and CMCC/CMCI with key words of＂perlecan, angiogenesis, cartilage, heparan sulfate, vascular endothelial growth factor.＂The manuscripts with the contents of perlecan expression and function published recently or in authoritative journals were included. Manuscripts with repetitive contents or Meta analysis were excluded. RESULTS AND CONCLUSION：A total of 129 manuscripts were included, and according to inclusion and exclusion criteria, 35 manuscripts were included in the final analysis. Perlecan plays a crucial role in tissue development.The underlying mechanism is possibly due to the interactions of the pericellular environment. Perlecan functions in a diverse range. Perlecan employs the same basic mechanism, based on interactions with growth factors, morphogens and matrix proteins.