经鼻持续气道正压通气联合一氧化氮治疗婴幼儿急性肺损伤

The clinical observation in infants with acute lung injury by nasal continuous positive airway pressure with NO

目的观察经鼻持续气道正压通气（NCPAP）联合一氧化氮（NO）治疗婴幼儿急性肺损伤（ALI）的临床疗效。方法选择2009年6月~2010年2月收治的ALI患儿36例,均符合吸入NO和（或）NCPAP指征。给予患儿抗感染、控制体液、改善循环、化痰、解痉等治疗,同时采用NCPAP并给予NO 10 ppm。观察患儿转归、治疗前后血气变化等情况。结果 36例患儿中,病情好转31例,转为有创通气5例。NCPAP治疗24 h后,患儿氧合指数由治疗前的（256.9±40.3）显著升至（347.2±41.6）,且患儿呼吸频率、心率均显著改善（P〈0.05）。结论 NCPAP联合NO相对无创,效果良好,患儿及家属接受度高。

Objective To observe and analyze the clinical effect of infants with acute lung injury（ALI） by nasal continuous positive airway pressure（NCPAP） with NO.Methods Thirty-six cases of ALI from June.2009 to Feb.2010 were given NCPAP and NO 10 ppm and treatment with resist infection,control body fluid,phlegm,and relieve muscle spasm.The development and the changes of blood gas of 36 infants were observed.Results The use of NCPAP significantly improved the arterial blood oxygenation after 24h.The blood oxygenation level was increased significantly from（256.9±40.3） to（347.2±41.6） and the values of HR,RR were significantly improved（P0.05）.Conclusion Using NCPAP and NO is of efficacy and safety in infants with acute lung injury.