控制性超促排卵中更换不同来源卵泡刺激素对IVF-ET结局的影响

The impact of replacement of different follicle-stimulating hormone during controlled ovarian stimulation on the result of in vitro fertilization and embryo transfer

目的分析在控制性超促排卵(COH)过程中,更换卵泡刺激素(FSH)对体外受精-胚胎移植(IVF-ET)周期结局的影响。方法对本院行IVF-ET的150例患者临床资料进行回顾性分析。其中50例患者在COH中将进口基因重组促卵泡激素(rFSH)更换为国产高纯尿促卵泡激素(uFSH)(研究组),100例患者在同期全程使用rFSH行COH(对照组)。比较2组患者促排卵情况和临床相关指标的区别。结果 2组促排卵时间、FSH用量、获卵数、MⅡ期卵子数、临床结局比较无显著性差异,研究组患者较对照组明显减少了药品费用。结论 COH过程中,以uFSH代替rFSH,不影响IVF-ET的结局,且费用更低。

Objective To evaluate the impact of replacement of different follicle-stimulating hormone during controlled ovarian stimulation（COH） on in vitro fertilization and embryo transfer.Methods 150 infertile women who underwent IVF-ET cycle were divided into 2 groups.Patients in research group replaced recombinant follicle-stimulating hormone（rFSH） with urinary follicle-stimulating hormone（uFSH） during COH while patients in control group received only rFSH during COH.Parameters concerning follicle stimulation and clinical effect were compared.Results Patients who replaced FSH saved drug expense significantly,and shared similar duration of COH,total dose of FSH,number of retrieved oocytes,number of MII oocytes,implantation rate,pregnancy rate,abortion rate and clinical outcome.Conclusion Replacement of rFSH with uFSH during COH does not influence the result of IVF-ET,and the cost is lower.