肾虚证与糖尿病遗传易感性的关联

Discussion on the Association of Kidney Deficiency with Diabetes Genetic Susceptibility

目的探讨肾虚证与2型糖尿病(T2DM)遗传易感性的关联性。方法从62个T2DM家系中筛选出年龄≥35岁的先证者(62例)的一、二级亲属188例,将包括先证者在内的250例家系成员分为T2DM组(136例)、糖耐量异常组(52例)和家系健康组(62例);并选取无糖尿病家族史且糖耐量正常者60例作为非家系健康对照组。按照68项肾虚辨证因子调查表的内容,对各组症状和体征作正常为"0"、异常为"1"的二值化计分,比较各组肾虚因子总计分的差异,并对各组排前10位的肾虚辨证因子进行统计。结果 T2DM组的平均年龄与其他3组比较差异有统计学意义(P<0.01),4组之间的性别差异无统计学意义(P>0.05),T2DM组的肾虚辨证因子总分显著高于糖耐量异常组(P<0.01),家系健康组的肾虚相关因子总分高于非家系健康对照组(P<0.01)。腰痛症状在T2DM组、糖耐量异常组、家系健康组中出现频率均列于前10位,分别占54.8%、53.2%和19.4%,而在非家系健康对照组中出现频率非常低。结论肾虚或肾虚体质在糖尿病家系中有可遗传倾向,此倾向与家系亲属糖尿病的遗传易感性有密切的联系。

Objective To explore the association of kidney deficiency with genetic susceptibility of type II diabetes mellitus （T2DM）. Methods Totally 188 cases of the first and second degrees of relatives of 62 probands, older than or equal to 35 years old, from the 62 T2DM families were screened out. The 250 family members, with the probands included, were divided into T2DM group （136 cases）, abnormal glucose tolerance group （52 cases）, and healthy family group （62 cases）. In addition, the other 60 people with normal glucose tolerance from the families without the history of diabetes were taken as the non-diabetes family healthy control group. According to the questionnaire on the 68 differentiation factors of kidney deficiency, for all groups, those without symptoms and signs were scored ＂0＂, and those with symptoms and signs were scored ＂1＂. The difference of the total scores of factors of kidney deficiency in all groups was compared and the top 10 differentiation factors of kidney deficiency in each group were statistically processed. Results There was statistical difference in the averaged age between the T2DM group and the other 3 groups （P〈0.01）. There was no statistical difference in the comparison of the 4 groups in the sex ratio （P〉0. 05）. The total score of differentiation factors of kidney deficiency of the T2DM group was significantly higher than that of the abnormal glucose tolerance group （P〈0. 01）. The total score of the related factors of kidney deficiency of the healthy family group was higher than that of the non-diabetes family healthy control group （P〈0. 01）. The appearance frequency of symptom lumbago in the T2DM group, abnormal glucose tolerance group, and healthy family group was always in the list of the top 10 factors, being 54.8%, 53.2%, and 19.4% respectively, however, in the non-diabetes family healthy control group it was very low. Conclusion There is a genetic tendency existing in the kidney deficiency or kidney deficiency constitution in diabetes families, and this tendency is closely associated with the diabetes genetic susceptibility Of the relatives of the family.