药用植物内生真菌—生物活性物质的新来源

Endophytic Fungi Living in Medicinal Plants as New Sources of Bioactive Substances

药用植物内生真菌资源丰富,具有潜在的应用前景。利用内生真菌发酵实现生物活性物质的工业化生产,可以提高其产量,同时有利于珍稀、濒危药用植物资源的保护,对减少野生药用植物多样性的破坏具有重要意义。文章综述了近年来国内外药用植物内生真菌及其次生代谢产物的研究概况和最新进展,并对研究中存在的问题进行了讨论及展望。

Endophytes are great resources,with potential application prospect. The industrial productions of bioactive substances that make use of endophytic fungi are capable of increasing their yields. In the meantime,it is conductive to the conservation of precious and endangered medicinal plants and it is also very important in avoiding the damage to the diversity of wild medicinal plants. The general situation and recent advances on the endophyte and its secondary metabolites researches focused on medicinal plants were summarized. It mainly reviews the researches of the secondary metabolites produced by endophytie fungus including antimicrobial, antineoplastic,antioxidative and other functional bioaetive substances. In addition, endophyte can promote the yields of secondary metabolites produced by its host medicinal plants. Besides it also plays an important role in the biotransformation of some natural products. Then the mechanism in which endophytes can synthesize bioactive substances similar to the secondary metabolites produced by host plants is investigated. Finally, the problem and prospect of endophytic fungi research were discussed and previewed.