口腔黏膜下纤维性变癌变的相关危险因素分析

The analysis on risk factors for carcinogenesis of oral submucous fibrosis

目的通过对461例口腔黏膜下纤维性变(oral subm ucous fibrosis,O SF)及62例O SF癌变患者进行回顾性综合分析,探讨O SF癌变的相关危险因素。方法首先进行单因素检验,观察年龄、性别、职务、文化程度、咀嚼槟榔的时间和频率、吸烟量、饮酒、是否伴发白斑或扁平苔藓、张口度等15个相关因素与O SF癌变的关系,筛选与O SF癌变相关的变量,进入多因素Logistic回归分析模型,计算这些因素的相对危险度(O R值)及95%的可信区间。结果单因素分析结果显示:年龄、文化程度、张口度、咀嚼槟榔、咀嚼槟榔的持续时间、吸烟、吸烟持续时间、吸烟量和饮酒被选入多因素Logistic回归分析模型;多因素Logistic回归结果显示年龄、咀嚼槟榔持续时间、吸烟及吸烟持续时间在O SF癌变过程中具有统计学意义(P<0.05)。结论年龄、咀嚼槟榔的持续时间、吸烟及吸烟持续时间是O SF癌变的危险因素。

【Objective】 To investigate the risk factors of malignant transformation of oral submucous fibrosis（OSF）.【Methods】 A total of 461 cases with OSF and 62 cases with malignant transformation of OSF were analyzed retrospectively.Single factor test was first performed to examine the associations between malignant transformation of OSF and each of risk factors including age,sex,occupation,educational level,duration of areca nut chewing,frequency of areca nut chewing,alcohol and tobacco consumption、mouth opening、accompanied by oral leukoplakia or oral lichen planus etal.Then the association of these selected factors with malignant transformation of OSF was evaluated using multiple logistic regression analysis.【Results】 Age,education,mouth opening,areca nut chewing,duration of areca nut chewing,smoking,duration and frequency of smoking,drinking were chosen as risk factors incorporated into the multiple logistic regression models.Multiple logistic regression analysis demonstrated that age,frequency of areca nut chewing,smoking and duration of smoking were associated with significantly increased risk for the malignant transformation of OSF（P〈0.05）.【Conclusion】 The risk factors for the malignant transformation of OSF were age,frequency of areca nut chewing,smoking and duration of smoking.