硫酰氟熏蒸灭鼠灭蠊效果及剂量与时间关系研究

Impact of dose and exposure time on deratting and disinsecting effects of sulfuryl fluoride

目的观察含量≥99.8%硫酰氟熏蒸灭鼠、灭蠊的效果,研究熏蒸剂量与熏蒸时间的关系。方法硫酰氟以4、8、12、16、20 g/m3浓度熏蒸,观察SD鼠和美洲大蠊毒毙的时间;用二次响应面回归拟合分析方法预测熏蒸剂量与时间的关系。结果 SD鼠和美洲大蠊在各组浓度的熏蒸中全部毒毙。其中SD鼠毒毙时间为43～381 min,美洲大蠊毒毙时间为97～387 min;建立熏蒸灭鼠二次响应面回归模型方程:=1.57-1.16X1-0.37X2+0.05X12+0.22X1X2+0.01X22以及熏蒸灭蠊二次响应面回归模型方程:=6.92-2.15X1-0.89X2+0.15X12+0.18X1X2+0.02X22。结论硫酰氟以4～20 g/m3的浓度熏蒸有良好的灭鼠、灭蠊作用,熏蒸浓度与熏蒸时间呈负相关,即熏蒸浓度下降,毒毙靶生物所需的时间延长;美洲大蠊对硫酰氟的抗性较SD鼠大。

Objective To determine the deratting and disinsecting effects of sulfuryl fluoride（≥99.8%） and their relationship with the dose and exposure time.Methods Rats and cockroaches were divided and fumigated with sulfuryl fluoride at 4,8,12,16,20 g/m3.The death time of SD rats and Periplaneta americana was recorded.Results were simulated and predicted using the response-surface model.Results All groups of subjects were killed at different concentrations of sulfuryl fluoride.The average time to death ranged from 43 to 381 minutes for SD rats and from 97 to 387 minutes for P.americana.The response-surface model for SD rats was established as： =1.57-1.16X1-0.37X2＋0.05X12＋0.22X1X2＋0.01X22 and that for P.americana： =6.92-2.15X1-0.89X2＋0.15X12＋0.18X1X2＋0.02X22.Conclusion Desired killing effect resulted from sulfuryl fluoride at 4 g/m3 to 20 g/m3,concentration was negatively correlated with the exposure time（i.e.the time to death increased as the concentration dropped）.Time and decrease of concentration.P.americana demonstrated stronger resistance to the agent compared with SD rats.