小秦艽化学成分研究

Study on the Chemical Constituents in Roots of Gentiana dahurica

目的:对陕西产小秦艽的化学成分进行系统研究。方法:采用硅胶柱及其他多种色谱手段对小秦艽的化学成分进行分离,采用UV、IR、NMR、MS等光谱手段,辅以对照品对照等方法鉴定化合物结构。结果:从陕西产小秦艽中分离得到7个化合物,分别鉴定为:栎瘿酸(1)、齐墩果酸(2)、β-谷甾醇(3)、胡萝卜苷(4)、龙胆苦苷(5)、獐牙菜苦苷(6)、獐牙菜苷(7)。结论:化合物1、2、4是首次从该植物中分离得到。

Objective： To systematically study the chemical constituents in the roots of Gentiana dahurica.Methods： Various column chromatographic techniques were used for isolation and purification.The structures were elucidated on the basis of spectral data（UV,IR,MS,NMR） and identified by comparing with the authentic substance.Results： Seven compounds were isolated and identified as： roburic acid（1）,oleanolic acid（2）,β-sitosterol（3）,daucosterol（4）,gentiopicroside（5）,swertiamarine（6）,sweroside（7）.Conclusion： Compounds 1,2 and 4 are isolated from this plant for the first time.