瑞舒伐他汀对脑梗死合并颈动脉粥样硬化斑块的影响

Effect of Rosuvastatin on Carotid Atherosclerotic Plaques in Patients with Cerebral Infarction

目的探讨瑞舒伐他汀对脑梗死合并颈动脉粥样硬化斑块的影响。方法选取60例脑梗死合并颈动脉粥样硬化斑块的病人,给予脑梗死正规治疗,并进行为期9个月的口服瑞舒伐他汀治疗。观察治疗开始前及治疗后3个月6、个月9、个月的血脂、C反应蛋白和治疗后6个月9、个月动脉斑块的变化,并用统计学进行分析。结果治疗3个月、6个月9、个月后,患者血清中TC、TG、LDL-C、及Hs-CRP水平较治疗前均有明显下降,同时HDL-C水平有所提高,与治疗前比较有显著统计学差异(P<0.05);治疗后6个月9、个月颈总动脉IMT及颈动脉斑块体积较治疗前有所下降,以治疗后9个月明显,比较有统计学差异(P<0.05)。结论瑞舒伐他汀对脑梗死合并颈动脉粥样硬化斑块患者可起到强化降脂及抑制、逆转斑块的作用,从而减少脑梗死的发生,是治疗该病的一种安全有效的药物。

Objective To observe the effect of Rosuvastatin on carotid atherosclerotic plaques in patients with cerebral infarction.Methods 60 cases of cerebral infarction patients with carotid atherosclerotic plaques received intervention treatment by rosuvastatin（10 mg daily） except general treatment.serum lipids,high-sensitivity CRP（hs-CRP） and carotid intima-media thickness（IMT） were measured before treatment,third month,sixth month and ninth month.Results Compared with the data before treatment,the level of Cholesterol（TC）,triglyceride（TG）,low-density lipoprotein Cholesterol（LDL-C） and hs-CRP decreased significantly at third month,sixth month and ninth month after the treatment（P0.05）,while the level of high-density lipoprotein cholesterol（HDL-C） increased significantly（P0.05）.At the same period,IMT and carotid atherosclerotic plaques score decreased significantly at ninth month after treatment（P0.05）.Conclusion Rosuvastatin could restrain and reverse carotid atherosclerotic plaques by decreasing the level of serum lipid.