小剂量托吡酯治疗小儿Tourette综合征疗效的初步观察

Observation on Curative Effect of Tourette Syndrome Treated with Topiramate

目的探讨托吡酯治疗小儿Tourette综合征(TS)的临床效果与合适剂量。方法本组40例儿童随机分为治疗组21例和对照组19例,两组均在心理治疗基础上进行药物治疗。治疗组采用托吡酯,剂量从0.5 mg/kg,1次/d开始,第2周增加1.0 mg/(kg.d),分2次服用,以后每1～2周增加0.5 mg/kg,最大剂量为3.0 mg/(kg.d),用药3个月后,依据抽动控制情况评定疗效,并观察药物不良反应;对照组采用氟哌啶醇4.0～12 mg/d,2次/d口服,治疗期间定期门诊复诊。结果治疗组有效率95.6%,对照组有效率85%,两组有效率比较有显著差异。结论小剂量托吡酯治疗TS比氟哌啶醇更有效,且副作用明显小。

Objective To discuss curative effect and dosage of topiramate to treat Tourette syndrome.Methods 40 cases of such patient were divided into therapy group（21 cases） and control group（19 cases）.On the bases of psychotherapy,the control group was treated with vesalium 4.0~12 mg/d bid.And therapy group was treated with topiramate of dosage from 0.5 mg/kg/d,to 1.0 mg/kg twice a day,and increased 0.5 mg/kg every one or two week to 3.0 mg/kg/d for 3 months.The curative effect and spasm condition were observed and followed in OPD.Results The effective rate was 95.6% in therapy group and 85% in control group with significant difference between two groups.Conclusion The small dosage of topiramate might have better curative effect with less side effect.