甘肃省2010年人群甲型H1N1流感病毒抗体水平监测

Monitoring the antibody levels of influenza virus A among the population of Gansu province in 2010

目的了解甘肃省2010年不同时期一般人群甲型H1N1流感(甲流)抗体水平变化及季节性流感抗体水平。方法采用血凝抑制(Hemagglutination Inhibition,HI)试验检测HI抗体,≥1:40为阳性。结果2009年8月、12月、2010年1月、2月、3月及9月底甘肃省城市人群甲流抗体阳性率分别为3.64%(11/302)、10.45%(44/421)、17.30%(55/318)、20.29%(70/345)、33.69%(94/279)和27.75%(111/400),9月份季节性流感H1N1、H3N2、B(Victorian)和B(yamagata)毒株抗体阳性率分别为30.25%(121/400)、15.50%(62/400)、12.75%(51/400)和5.00%(20/400)。结论甘肃省甲流首先在学生中出现,甲流HI抗体水平从流行初期的3.64%逐步上升至流行结束的33.69%;2010年9月人群中甲流及季节性H1N1流感病毒抗体阳性率相对较高,H3N2及B(yamagata)系病毒抗体阳性率较低。建议加强流感疫苗的接种,做好学校等集体单位流感样暴发疫情的防控工作。

Objective To investigate the influenza A（H1N1） antibody levels in different periods and seasonality antibody levels among the common people in Gansu province in 2010.Method Using hemagglutination-inhibition（HI） test to detect HI antibody,HI-titer more than 1：40 was positive.Results The H1N1 antibody positive rate of urban population in Gansu were 3.64%（11/302）,10.45%（44/421）,17.30%（55/318）,20.29%（70/345）,33.69%（94/279） and 27.75%（111/400） in August,Dec of 2009 and Jan,Feb,Mar,Sept of 2010,respectively.The seasonality antibody positive rate of H1N1,H3N2,B（Victorian）,B（yamagata） were 30.25%（121/400）,15.50%（62/400）,12.75%（51/400） and 5.00%（20/400）,respectively.Conclusions In Gansu,influenza A（H1N1） first appeared among students and the antibody level rose from 6.65% at the early and escalate to 33.69% at the end.In Sep of 2010,the influenza virus antibody positive rate of influenza A（H1N1）and seasonality H1N1 were high,but it was lower in H3N2 and B（yamagata）.As the result,we suggested to enhance the inoculation rate of influenza vaccine and do better control and prevention work of schools and other collective units.