早期肺癌手术治疗后的局部复发情况分析

Analysis of early lung cancer with local recurrence after surgical treatment

目的探讨早期肺癌术后局部复发的相关因素。方法收集在该院定期复查确诊的262例临床I期肺癌术后复发的病例，对术后局部复发的因素进行统计分析。结果262例患者局部复发25例，复发率为9．5％（25／262）；复发时间3-46个月，平均（22．8±10．3）个月；不同性剐和年龄肺癌患者的术后局部复发率无显著性差异（P〉0．05），而不同病理类型、手术方式、分化程度、病变部位、术前CEA浓度和肿瘤最大径的术后局部复发率有显著性差异（P〈0.05或0.01）。术前CEA浓度和分化程度进入最佳回归方程。结论病理类型、手术方式、分化程度、病变部位、术前CEA浓度和肿瘤最大径是早期肺癌术后局部复发的危险因素，术前CEA浓度和分化程度是高危独立因素。

[ Objective] To investigate the correlation factor of early lung cancer with local recurrence after surgical treatment. [Methods] Retrospective analysis of 262 cases of stage- I lung cancer with local recun＇ence postoperatively was rechecked and diagnosed in our hospital. Statistical analysis of the relevant factors of local recurrence postoperatively was made. [Results] There were 25 cases local recurrence in 262 cases, the recurrence rate was 9.5% （25/262）; recurrence time at 3 to 46 months, an average （22.8±10.3） months; local recurrence of iung cancer patients showed no significant difference in different gender, age （P 〉0.05）, the local recurrence rates were signifi- candy different in different pathological types, surgical methods, degree of differentiation, diseased region, preopera- tive CEA concentration and maximum tumor diameter （P 〈0.05 or 0.01）. Preoperative CEA concentration and the degree of differentiation were the best regression equation. [ Conclusion ] The pathological types, surgical method, degree of differentiation, diseased region, preoperative CEA concentration and maximum tumor diameter are early Hsk factors of local recurrence in lung cancer, preoperative CEA concentration and the degree of differentiation are independent risk factors.