痰热清注射液联合支气管动脉化疗灌注治疗肺癌临床研究

The Reseach On Effect of Tanreqing Injection for Lung Cancer After Bronchial Arterial Infusion

目的:通过观察痰热清注射液对肺癌支气管动脉化疗灌注术后中医证候、不良反应等指标的前后对比,探讨痰热清注射液对肺癌支气管动脉化疗灌注术后的辅助作用。方法:本课题采用随机、对照的研究方法,将符合标准的40例肺癌患者随机分为治疗组和对照组,每组20例,治疗组:介入治疗+中药痰热清注射液,痰热清注射液每日1次30mL静脉滴注,1周为1个疗程,术后给予西医常规对症处理。对照组:单纯介入治疗,术后给予西医常规对症处理,两组患者均行支气管动脉化疗灌注术:化疗药物为卡铂0.2g(或顺铂80mg)、CTX0.6g和THP40mg。采用改良式Seldiner技术,行选择性和超选择性支气管动脉插管,经导管缓慢注入化疗药物。记录两组患者术前、术Ridit检验方法,用SPSS13.0统计软件进行分析。结果:术后治疗组中医证候、疗效总有效率、不良反应发生率等观察指标,较对照组均有较明显的提高。结论:中药痰热清注射液作为肺癌介入化疗的辅助用药,能有效改善术后发热等中医证候,减轻化疗的毒副作用,提高患者的生存质量,具有独特的优势,值得进一步研究并在临床推广应用。

Objective：The object of this study was to discuss the assistant effect of Tanreqing Injection for lung cancer,which is used in the chemotherapy douche operation of Bronchial Artery.The study was done by using a kind of Chinese Traditional Medicine-Tanreqing Injection for Lung cancer treatment,in which we observe many indexes before and after the chemotherapy douche operation of Bronchial Artery,such as the Chinese traditional symptom,and the ill reaction after the operation and so on.Methods：This study was designed to adopt a random and compared way.We average 40 cases of lung cancer into two teams,all of cases are up to snuff,one team is named therapy team and the other is comparison team.The therapy team：add Chinese traditional medicine—Tanreqing injection into Intervention treatment,the way of Tanreqing injection is one time per day,30ml per time by mainline,symptomatic patients given Western medicine to deal with.The comparison team：Intervention treatment,conventionally use antibiotic after operation only,Symptomatic patients given Western medicine to deal with.Both of the teams we use the same chemotherapy douche operation of bronchial artery,in which the chemotherapy medicines are Carboplatin 0.2g（or DDP 80mg）,CTX0.6g and THP 40mg.The study was carried out by meliorative Seldiner technique,that we use selective and over-selective Bronchial Artery intubatton to inject chemotherapy medicines slowly by catheter.To write down the data happened before and after the operation,such as the numbers of blood routine in the 7th day,liver and kidney’s function,the impersonal effect of tumor,curative effect of Chinese traditional symptom,and the degree of ill-reaction.We put up all the data into statistical analysis,for example,we use χ2 test way for the number data,and Ridit test way for grade data,SPSS13.0 statistical software for analyze at last.Result：By observing the degree and consistent time of the effective ratio of Chinese traditional symptom,the overall efficacy ratio and the ratio of ill reaction happened after the operation,all the indexes we recorded show that the therapy team is better than the comparison team.Conclusion：As the assistant medicine in treatment of lung cancer by interventional chemotherapy,Tanreqing Injection can change the Chinese traditional symptom effectively and also can release the toxic effect of chemotherapy,especially have particular advantages to enhance the patients’ live quality.It is worthy of spreading wildly in clinical treatment.