冠心舒通胶囊对动脉粥样硬化大鼠血脂代谢及血流变指标的影响

Effects of Guanxin Shutong Capsule on Lipid Metabolism and Hemorrheology in Rat Model with Experimental Atherosclerosis

目的:观察冠心舒通胶囊对高脂喂养诱导早期动脉粥样硬化大鼠模型血脂代谢及血液流变学指标的影响,探讨冠心舒通胶囊抗动脉粥样硬化的作用以及可能的作用机制。方法:32只Wistar大鼠随机平均分为4组,正常对照组(NC),普通饲料喂养加冠心舒通胶囊喂养组(NG),高脂饲料喂养组(HG),高脂加冠心舒通胶囊喂养组(GG),连续喂养6周,实验末测定大鼠血脂(TC,TG,LDL)水平和血液流变学各项指标。结果:GG组与HG组相比各项指标明显降低(P<0.05),而NG组与NC组相比未得出显著性差异(P>0.05)。结论:冠心舒通胶囊可以降低动脉粥样硬化大鼠的血脂,调节血液流变学指标,从而保护血管,起到抗动脉粥样硬化的作用。

Objective：To observe the effects of Guanxin Shutong capsule on lipid metabolism and hemorrheology in rat model with experimental atherosclerosis and explore its possible mechanism.Method：Guanxin Shutong thirty-two Wistar rats were randomly divided into normal control group（n=8）,normal fed plus capsule group（n=8）,high fat fed group（n=8）,high fat fed plus Guanxin Shutong capsule group（n=8）.Rats were fed for six weeks.Serum lipids and hemorrheological index were detected at the end of the experiment.Result：There was significantly difference in the serum lipid and hemorrheological index between GG group and HG group（P〈0.05）,but no significant difference was found between NC group and NG group（P〉0.05）.Conclusion：Guanxin Shutong capsule can reduce the serum lipids and hemodynamics index so as to protect vessels and inhibit the formation of experimental atherosclerosis in rats.