舒芬太尼用于重度妊高征患者剖宫产术后硬膜外镇痛的临床观察

Clinical Observation of Sulfentanil for Cesarean section postoperative epidural analgesia of severe pregnancy hypertension

目的观察舒芬太尼用于重度妊高征患者剖宫产术后硬膜外自控镇痛的效果和不良反应。方法将择期重度妊高症剖宫产术患者随机分为A组(舒芬太尼组)、B组(吗啡组)和C组(对照组),每组40例。镇痛药液为:A组0.125%罗哌卡因+0.005%舒芬太尼,B组0.125%罗哌卡因+0.0001%吗啡,C组0.125%罗哌卡因,均采用负荷量+持续剂量给药模式。结果镇痛效应:VA S评分A组、B组均取得满意效果,C组满意度明显低于A、B组(P<0.01);恶心、呕吐、皮肤瘙痒发生率A组明显低于B组,有统计学差异(P<0.05或P<0.01)。结论舒芬太尼用于重度妊高征剖宫产术后硬膜外镇痛可取得满意的镇痛效果,且不良反应发生率明显低于吗啡。

【Objective】 To view the effects and adverse reactions of Sulfentanil in patient-controlled epidural analgesia after severe pregnancy hypertension surgery.【Methods】 patients suffered from severe pregnancy hypertension who were scheduled for surgery were randomly divided into A（sulfentanil group）,B group（morphine group） and C group（control group）,each 40 cases.The analgesic liquid is： A group of 0.125% ropivacaine ＋0.005% sulfentanil,B group of 0.125% ropivacaine ＋0.0001% morphine,C group of 0.125% ropivacaine,the loading and continuous dosing mode are used in each group.【Results】 Analgesic effect： group A and B have achieved satisfactory results on VAS score,while C group＇s satisfaction was significantly lower than A and B group（P0.01）;The incidence of nausea,vomiting and skin itching in groupwere A is significantly lower than B group,which are statistically significant difference（P0.05 or P0.01）.【Conclusion】 Sulfentanil for epidural analgesia after cesarean section with severe pregnancy hypertension can achieve satisfactory analgesia,and the incidence of adverse reactions was significantly lower than morphine.