胸腔置管闭式引流尿激酶胸腔内注射治疗和预防结核性胸膜炎胸膜肥厚粘连疗效观察

Observing the effect of injecting urokinase into chest by chest catheter closed drainage to treat and prevent tuberculous pleurisy pleural adhesions hypertrophy

目的观察胸腔置管闭式引流尿激酶胸腔内注射治疗和预防结核性胸膜炎胸膜肥粘连的疗效。方法 88例结核性渗出性胸膜炎患者随机分为治疗组和对照组各44例。治疗组胸腔置管闭式引流后胸腔内注入尿激酶10万IU+生理盐水20 mL,隔日1次,3次为一疗程。对照组胸腔置管闭式引流后胸腔内注入生理盐水20mL,方法同治疗组,化疗方法及其它治疗方法两组相同。结果引流总液量:治疗组(3461±531)mL,对照组(2889±476)mL,两组比较有显性差异(P<0.05),出院时测胸膜厚度,治疗组(1.21±0.26)mm,对照组(1.61±0.39)mm,两组比较有显者性差异(P<0.01),胸膜粘连发生率:治疗组14%,对照组41%(P<0.05)。结论尿激酶胸腔内注射治疗和预防结核性胸膜炎胸膜肥厚粘连有良好的效果,与对照组相比有显著性差异。

【Objective】 Observing the curative effect of injecting urokinase into chest by chest catheter closed drainage to treat and prevent tuberculous pleurisy pleural adhesions hypertrophy.【Methods】 Divide 88 tuberculous exudative pleurisy patients randomLy into therapy group and control group;every group has 44 patients.For therapy group,inject urokinase 10 millions IU＋20mL saline through chest catheter closed drainage one time in 2days,3 times a course.For control group,only inject 20 mL saline into chest,also one time in 2 days,3 times a course.For the two groups,chemotherapy and other treatments are the same.【Results】 For the therapy group,the volume draining from chest is 3461＋-531mL.While for the control group,the volume is 2889＋-476mL,which two have obvious differences（P0.05）.When patients leaving hospital,the rate of pleural adhesions is 14%,while the control group is 41%（P0.05）.【Conclusion】 Injecting urokinase into chest to treat and prevent tuberculous pleurisy pleural adhesions hypertrophy has a very good effect.Compared to the control group,this treatment has obvious differences.