造血干细胞移植后发生口腔黏膜炎71例临床分析

Clinical analysis of 71 patients with oral mucositis following hematopoietic stem cells transplantation

目的探讨造血干细胞移植(HSCT)后口腔黏膜炎(OM)的发生情况、影响因素及处理措施。方法对北京大学人民医院2009年行HSCT的166例患者中发生OM的71例患者的资料进行临床分析。结果 OM的愈合率为95.77%,平均愈合时间为移植后(17.61±8.36)d。患者性别、年龄、HLA配型及预处理方案对OM愈合时间均无明显影响(P>0.05)。结论性别、年龄、HLA配型及预处理方案对OM愈合时间无明显影响。通过及时有效的口腔处理,可降低OM发生率,即使重度OM也可良好愈合。

Objective To explore the incidence,influence factors and treatment methods of oral mucositis（OM） following hematopoietic stem cells transplantation（HSCT）.Methods A clinical analysis about the total 71 OM cases occurring after HSCT among 166 patients in Peking University People＇s Hospital during 2009 was completed.Results The healing rate of OM was 95.77% and the average healing time was（17.61±8.36） d after HSCT.There were no obvious effects of gender,age,HLA matches,conditioning regimen to the healing time of OM（P0.05）.Conclusion Gender,age,HLA matches and conditioning regimen have no obvious effects on healing time.By given timely and effective treatment,the incidence of OM can be reduced and even severe OM can also be well cured.