慢性鼻-鼻窦炎术后应用黏液调节剂的临床疗效观察

Clinical observation of mucoregulatory agents' application after chronic rhinosinusitis surgery

目的:观察2种不同的黏液调节剂在鼻内镜围手术期的作用。方法:97例慢性鼻-鼻窦炎患者随机分为3组:对照组(A组)33例、盐酸氨溴索组(B组)31例、桉柠蒎组(C组)33例。在常规治疗基础上,A组患者不服用任何黏液调节剂;B组术后3 d开始口服盐酸氨溴索片30 mg,3次/d,连续应用8周;C组术后3 d开始口服桉柠蒎肠溶软胶囊300 mg,3次/d,连续应用8周。3组患者均随访6个月,观察治疗效果。结果:B组有效率90.3%,C组有效率97.0%,2组比较差异无统计学意义;A组有效率75.8%,与C组比较差异有统计学意义(P<0.05),与B组比较差异无统计学意义(P>0.05)。结论:应用黏液调节剂可以明显改善术后黏膜分泌、上皮化,缩短术后换药时间,提高功能性鼻内镜手术的成功率,有良好的临床应用前景。

Objective：To explore the effect of mucoregulatory agents during endoscopic sinus surgery.Method：Ninety-seven cases with chronic rhinosinusitis were randomly divided into three groups,with 31 cases in B group treated by ambroxol,33 cases in C group treated by eucalyptol-limonene-pinene enteric soft capsule and 33 cases in control group（A group）.The follow-up visit lasted for 6 months for three groups.Then,the therapeutic effects were evaluated and compared among these three groups.Result：By the end of 6 months after treatment,the effective rate was 90.3% and 97.0% for cases in the B and C groups respectively,and only 75.8% in A group.The difference between A and C was statistically significant（P0.05）.Conclusion：Eucalyptol-limonene-pinene enteric soft capsule,as a multicomponent mucoregulatory agent,can obviously improve the secretion of mucosa and epithelial recovery,thus accelerate healing of the disease.It can also improve the success rate of functional endoscope sinus surgery,and may play a promising role in clinical application.