多孔复合掺杂聚磷酸钙支架骨修复材料的制备及其性能(英文)

Preparation and properties of porous co-substituted calcium polyphosphate scaffold as bone repair material

背景:离子掺杂是生物陶瓷改性的一种重要方法。目的:评估复合掺杂生物陶瓷作为骨修复材料的可行性。方法:将钾离子和锶离子复合掺入聚磷酸钙中,制得一种新型骨修复材料—KSCPP。采用扫描电镜和X射线衍射检测分析聚磷酸钙和KSCPP的微观结构和结晶情况;采用抗压强度测试实验、体外降解实验、体外细胞培养实验表征KSCPP的性能,并且进行短期兔肌肉植入实验观察KSCPP的组织相容性。结果与结论:与羟基磷灰石和聚磷酸钙相比较,KSCPP支架材料拥有更高的抗压强度和更快的降解速度及更低的细胞毒性和更好的组织相容性。

BACKGROUND：Ions doping is an important method for the modification of bioceramic.OBJECTIVE：To evaluate a novel co-substituted bioceramic scaffolds as bone repair material.METHODS：The microstructure and crystallization of the scaffolds were detected by scanning electron microscope and X-ray diffraction.Compression strength test,degradation test and cell culture experiment were assumed to evaluate the properties of KSCPP in vitro.After a short period of muscle pouches implantation,the performance of KSCPP in vivo was evaluated.RESULTS AND CONCLUSION：The results show that KSCPP scaffold has a higher compressive strength and degradation rate.Moreover,the MTT assay and implantation test reveal that the KSCPP scaffold exhibits lower cytotoxicity and better tissue biocompatibility than CPP and HA.The study proved the great potential of KSCPP in bone repair applications.