三联疗法治疗胃幽门螺旋杆菌感染疗效观察

The Treatment Efficacy Observation of Triple Therapy of H.pylori Infection

目的：客观评价三联疗法治疗胃幽门螺旋杆菌感染的临床疗效.方法：以本院2008年1月～2009年1月收治的48例患者组成对照组,以2009年1月～2010年1月收治的48例患者作为观察组,对照组给予奥美拉唑＋阿莫西林进行治疗,观察组给予泮托拉唑＋克拉霉素＋左氧氟沙星三联药物进行治疗.治疗1周后停药,6～8周后观察并对比两组的临床疗效.结果：对照组根治率41.67%（28/48）,观察组根治率为89.58%（43/48）,观察组根治率显著优于对照组,χ2=12.1690,P〈0.01,具有统计学差异性.结论：三联药物疗法可显著提高胃幽门螺旋杆菌感染的根治率,具有起效快、疗效确切的优势,建议在临床治疗中广泛推广应用.

Objective：Evaluate Objectively the clinical efficacy of triple therapy of H. pylori infeetion.Methods：48 patients treated in our hospital from Jan＇uary 2008 to January 2009 composed the control group,48 patients admitted to our hospital from January 2009 to January 2010 composed the observation group）the control group was given omeprazole ＋ amoxicillin for treatment,the observation group was given pantoprazole ＋ clarithromycin＋ levofloxacin triple drug treatment.Withdrawal after one week treatment.observed and compared the clinical efficacy of the two groups.Results：The cure rate of the control group is 41.67% （28/48）,the observation group is 89.58%（43/48）,radical observation group are significantly better than the control group, x^2=12.1690,P〈0.01,with statistically difference. Conclusion：Triple drug therapy can significantly increase the cure rate of H.pylori infection,with the advantage of rapid onset and curative effect.widely recommended in clinical application.