原发性高血压左室肥厚与血压变异性的关系

The Relationship between Left Ventricular Hypertrophy and the Progress of Blood Pressure Variability

目的:探讨原发性高血压(EH)患者左室肥厚(LVH)与血压变异性(BPV)的关系。方法:143例EH患者根据超声心动图测定的左室重量指数(LVMI)分为LVH组及不伴LVH(单纯高血压)组,运用24h动态血压(ABPM)监测技术,与正常对照组分别计算BPV。比较各组之间的差异,并分析BPV与LVMI之间的关系。结果:与对照组相比,LVH组及不伴LVH组均显示BPV明显升高,L★H组BPV较不伴LVH组明显升高。结论:EH患者体内自主神经功能失衡,交感与副交感神经的双重损害参与了高血压的左室重构机制,可能伴随左室重构过程。BPV是评价心血管自主神经活动的无创指标与高血压靶器官损害关系密切。

Objective：To investigated the clinical significance of blood pressure variability （BPV）in essential hypertension with left ventricular hypertrophy（LVH）.Methods： 143 essential hypertensive patients and 46 control persons received examinations by 24-hour ABPM.The patients were divided into 2 groups by the result of LVM1. BPV parameters were observed.Results;BPV in hypertension group With or without left ventrieular hypertrophy was significantly higher than control group.And BPV in hypertension was significantly higher than control group,Conclusion：There was autonomic nerve imbalance in essential hypertension.The impairment of sympathetic and parasympathetic function might be involved in pathogenesis of left ventrieular remodeling.The degree of impairment seemed to be ongoing severe in the modeling process of leR ventricular structttre.BPV has been regarded as an independent index reflecting autonomic nervous system in eardiovascular regutation,BPV has a close relationship with target organ damage of hypertension.