生长抑素治疗术后早期炎性肠梗阻的临床研究

Application of Somatostatin in Early Postoperative Inflammatory Small Bowel Obstruction

目的:本研究旨在通过大宗的临床病例对照观察,明确生长抑素(施他宁)能加速或促进EPISBO的康复。方法:将2008年1月至2010年12月期间我科术后发生的70例术后早期炎性肠梗阻患者,按照随机对照的原则,分为常规组(对照组,33例)和生长抑素加常规方法治疗组(治疗组,37例),观察比较两组患者临床疗效,住院时间,费用,并动态观察实验室CPK(Creatine phosphoric acid activatingenzyme)检查变化。结果:(1)两组70例患者均采用保守方法治愈,无肠绞榨中转手术病例:(2)治疗组临床疗效较对照组疗效明显,平均住院时间明显缩短,费用有所下降。结论:生长抑素能抑制消化道内液分泌、缓解扩张、促进肠蠕动,对治疗术后早期炎性肠梗阻缓解有明显促进作用,缩短其病程,能减轻患者痛苦,促进其早日康复,减少住院时间。

Objective： This research aims to make it clear that somatostatin can accelerate or promotc the EPISBO recovery through contrastive observation among a large number of clinical cases.Methods： We divide, according to the principle of randomized control, the 70 cases of EPISBO in our departlnent from January 2008 to December 2010 into the regular trcatmcnt group （the control group, 33 cases） and the somatostatin plus regular treatment group （somatostatin group, 37 cases）, observe and contrast the clinical curative effects, lhe length of stay and the cost of the two groups, and observe dynamically the result of lab CPK （Creatine phosphoric acid activating cnzyme）. Results： （1）The 70 patients in the two groups all adopt the conservative method to treat the case of nun-intestinaI colic by being transferred to the operation. （2）The clinical curative effect of the somatostatin group is more obvious than that of the control group： the average time in hospital reduces obviously and the expense drops. And the result of the iconography inspection are gets impwved. Conclusion： Somatostatin can suppress the fluid secretion in the digestive tract, alleviate the expansion and promote intestinal peristalsis. It plays an obvious role in dealing with EPISBO, like shortening its course, alleviating the pain of the patients, advancing its reeovc^7 and shortening the length of stay in hospital.