急性轻中型颅脑损伤患者血清中S-100B蛋白的动态变化及预后分析

The Dynamic Changes of S-100B Protein and Prognosis Analysis on Acute Craniocerebral Injury of Light and Medium Type

目的:探讨S-100B蛋白对轻中型颅脑损伤的诊断意义和预后价值。方法:选择轻型颅脑损伤患者30例(轻型组),中型颅脑损伤患者30例(中型组)以及健康人士30例(对照组),检测并比较各组血清S-100B蛋白水平,另将其结果与伤后3个月格拉斯哥预后评分(GOS)进行相关性分析。结果:轻型组和中型组S-100B蛋白浓度均与对照组有显著性差异,轻型组与中型组比较也有显著性差异,GOS结局评分与S-100B蛋白浓度呈显著负相关(r=-0.347,p<0.05)。结论:S-100B蛋白指标具有较高的灵敏性和准确性,检测简单,可更为早期的判断颅脑损伤程度和预后,从而为临床诊断和治疗提供参考。

Objective：To explore the diagnostic meaning and prognosis evaluation of S-100B protein on acute craniocerebral injury of light and medium type. Methods： S-100B protein of fight type group （30 cases）, medium type group （30 cases） and control group （30 cases） were detected, and the result and GOS were given correlation mlalysis. Results： Compared with control group, GOS of light type group and medium type group had significant difference, and the comparation between light type group and medium type group showed significant difference, too. S-100B protein and GOS had significant correlation（r=-0.347,p〈0.05）. Conclusion： S-100B protein has high sensitivity and veracity, can judge the injury degree and prognosis at early stage, and provide guidance for clinical diagnose and therapy