铜绿假单胞菌296株临床分布及耐药性分析

Clinical distribution and resistance analysis of 296 strain pseudomonas aeruginosa

目的通过分析296株铜绿假单胞菌的分布和耐药情况,为医院感染控制及临床合理用药提供依据。方法应用回顾性调查方法分析沈阳医学院奉天医院2010-01-01-2010-12-01分离到的296株铜绿假单胞菌的临床分布及耐药性。结果 296株铜绿假单胞菌主要来源于痰液标本,主要集中于呼吸内科、ICU等科室;其耐药率最低的是头孢哌酮/舒巴坦和哌拉西林/他唑巴坦。结论铜绿假单胞菌是临床常见的病原菌,对哌拉西林/他唑巴坦和头孢哌酮/舒巴坦有较高的敏感性,但总的耐药率仍很高,可根据药敏结果合理选择用药。

Objeetive Io provide the basis for infection control and rational drug use in hospitals by analysis of 296 clinical isolates of Pseudomonas aeruginosa. Methods The clinical distribution and antimicrobial drug resistance of 296 strains Pseudomonas aeruginosa detached in Fengtian Hospital affiliated to Shenyang Medical College from 2010- 01-01--2010-12-01 were analysed by retrospective study. Results 296 isolated strains of Pseudomonas aeruginosa were mainly from the respiratory tract specimens, accounting for 74.0 % ,and mainly in respiratory department, ICU and neurosurgery departments,accounting for 52.7 %;the resistance rate of cefoperazone/sulbactam was the lowest 9. 1% and piperacillin/tazobactam 12.2 %, followed by levofloxacin 17.2 %, polymyxin B20.9 %. Conclusion Pseudomonas aeruginosa is a common clinical pathogenic bacteria sensitive to piperacillin/tazobactam and cefoperazone/ sulbaetam,but the overall resistance rate is still high. It should choose a single or several drugs in combination ac- cording to the the susceptibility results.