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机体的免疫反应是如何被激活的?——2011年诺贝尔生理学或医学奖解读 被引量:2

How The Body's Immune Response Is Activated?——The Interpretation of 2011 Nobel Prize in Physiology or Medicine
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摘要 2011年10月3日,举世瞩目的2011年诺贝尔生理学或医学奖在瑞典卡罗林斯卡医学院揭晓”.因在免疫学领域取得杰出成就,美国科学家布鲁斯·博伊特勒(Bruce A.Beutler)、法国科学家朱尔斯·霍夫曼(Jules A.Hoffmann)和加拿大科学家拉尔夫·斯坦曼(Ralph M.Steinman),共同分享了这一奖项. The 2011 Nobel Prize in Physiology or Medicine is announced. Bruce A. Beutler and Jules A. Hoffmann received one-half of the 2011 Nobel Prize in Physiology or Medicine, for their discoveries concerning the activation of innate immunity; the other half went to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity. Three winners' work has revolutionized our understanding of the immune system. And it has a bright prospect in the applied domain of anti-infections immunity, organ transplantation, and treatment of autoimmune diseases.
作者 奇云 李大可
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2011年第10期900-907,共8页 Progress In Biochemistry and Biophysics
关键词 诺贝尔生理学或医学奖 免疫反应 美国科学家 激活 机体 解读 免疫学 医学院 The Nobel Prize, immune system, dendritic cells, Toll-like receptors
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参考文献17

  • 1Callaway E. Nobel announcement marred by winner's death. Nature, 2011,478:13-14.
  • 2Lemaitre B, Nicolas E, Michaut L, Reichhart J M, Hoffmann J A. The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in drosophilaadults. Cell, 1996, 86(6): 973-983.
  • 3Hoffmann J A, Kafatos F C, Janeway C A, et al. Phylogenetic perspectives in innate immunity. Science, 1996, 284 (5418): 1313-1318.
  • 4Poltorak A, He X, Smimova I, Liu M Y, Van Huffel C, Du X,Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science, 1998, 282(5396): 2085-2088.
  • 5Steinman R M, Cohn Z A. Identification of a novel cell type in peripheral lymphoid organs of mice.I. Morphology,quantitation, tissue distribution. J Exp Med, 1973,137(5): 1142-1162.
  • 6张彩,田志刚.天然免疫识别机制及天然免疫受体的相互调节[J].生物化学与生物物理进展,2008,35(2):124-128. 被引量:6
  • 7王梁华,司宇红,焦炳华.Toll样受体及其信号转导[J].生物化学与生物物理进展,2001,28(3):304-308. 被引量:13
  • 8孙冰,韩代书.Toll样受体信号通路的负调控[J].生物化学与生物物理进展,2009,36(12):1516-1522. 被引量:31
  • 9Steinman R M, Cohn Z A. Identification of a novel cell type in peripheral lymphoid organs of mice.II . Functional properties in vitro. J Exp Med, 1974, 139(2): 380- 397.
  • 10Steinman R M, Lustig D S, Cohn Z A. Identification of a novel cell type in peripheral lymphoid organs of mice. III . Functional properties in vivo. J Exp Med, 1974, 139(6): 1431-1445.

二级参考文献118

  • 1张浩,郑树森,蒋国平,周琳,谢海洋.小鼠肝癌树突状细胞融合瘤苗抗肿瘤作用的研究[J].中华肝脏病杂志,2004,12(11):648-651. 被引量:11
  • 2魏海明,邬鹏,田志刚.NK细胞识别的新模式——压力诱导模式[J].中国肿瘤生物治疗杂志,2005,12(2):85-88. 被引量:5
  • 3王海坤,韩代书.Toll样受体(TLRs)的信号转导与免疫调节[J].生物化学与生物物理进展,2006,33(9):820-827. 被引量:60
  • 4韩秋菊,张彩,张建,田志刚.干扰RNA的非靶免疫副作用及其siRNA序列设计与化学修饰[J].生物化学与生物物理进展,2007,34(4):343-347. 被引量:3
  • 5焦炳华 曾庆贵 等.细菌内毒素的结构与功能.中华内科理论与实践,5[M].成都:四川科学技术出版社,1998.567-573.
  • 6Fischer M, Ehlers M. Toll-like receptors in autoimmunity. Ann N Y Acad Sci, 2008, 1143:21-34.
  • 7Wang J, Hu Y, Deng W W, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect, 2009, 11(3): 321 -327.
  • 8O'Neill L A, Bowie A G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol, 2007, 7 (5): 353-364.
  • 9Creagh E M, O'Neill L A. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol, 2006, 27(8): 352-357.
  • 10Kuroishi T, Tanaka Y, Sakai A, et al. Human parotid saliva contains soluble toll-like receptor (TLR) 2 and modulates TLR2-mediated interleukin-8 production by monocytic cells. Mol Immunol, 2007, 44(8): 1969-1976.

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