不同器官浸润性微乳头状癌形态病理学及基础研究进展

Progress in Pathomorphology and Basic Research of Invasive Micropapillary Carcinomas in Different Organs

浸润性微乳头状癌是一种少见的具有特殊形态学特征以及高淋巴结转移、高淋巴管浸润等预后不良生物学行为的恶性肿瘤。近年来研究发现其可以发生在不同的器官,包括乳腺、膀胱、肺、唾液腺、腮腺、结肠、胆管、胃和卵巢等,染色体异常在其发生、发展过程中发挥了重要作用。作者综述了各器官浸润性微乳头状癌的形态病理学及基础研究进展。

Invasive micropapillary carcinoma is a rare malignant tumor with distinct pathomorphology and biological behaviorsexhibiting unfavorable prognoses, such as high-risk lymph node metastasis and high-degree lymphovascular invasion. Over the past few years, studies have found that this tumor can occur in various organs including the breast, urinary bladder, lung, salivary glands, colon, bile duct, stomach, and ovaries. Chromosomal aberration plays a key role in tumorigenesis and progression of a tumor. In the present article, progress in the pathomorphology and genetics of invasive micropapillary carcinomas in different organs was reviewed.