慢性苯中毒与ABO血型的关系

Investigation relationship between chronic benzene poisoning and ABO blood type

目的 探讨慢性苯中毒与ABO血型之间的关系。方法 选择上海地区1014名苯作业人员、4196名杨浦区非苯作业人员，进行ABO血型鉴定，并与我国汉族、上海地区汉族人群的血型分布进行比较；将71例慢性苯中毒患者与苯作业人员的ABO血型进行比较。结果我国汉族、上海地区和上海市杨浦区汉族非苯作业人群的血型分布频率比较，差异无统计学意义（x^2=7．95，P〉0．05）。慢性苯中毒患者A型血分布频率为42．25％，明显高于苯作业人员（29．48％），差异有统计学意义（x^2=5．11，P〈0．05。慢性苯中毒患者B型血分布频率为12.68％，明显低于苯作业人员（25．15％），差异有统计学意义（x^2=5．61，P〈O．05）。慢性苯中毒患者和苯作业人员正常人群的O型、AB型血分布频率比较，差异无统计学意义（P〉0．05）。结论A型血人群对慢性苯中毒更具易感性，B型血人群对慢性苯中毒具有一定的抵御力。

Objective To explore the relevance between chronic benzene poisoning and ABO blood type. Methods 1014 benzene-exposed workers chosen from Shanghai and 4196 non-benzene-exposed workers chosen from Yangpu district were accepted the ABO blood type identification, and two groups of workers compared with the Han population of Shanghai and China for the ABO blood type distribution; the 71 cases of chronic benzene poisoning were compared with the group of benzene-exposed workers for the ABO blood type distribution. Results There were no significant differences of the ABO blood type distribution among the Han population of China, the Han population of Shanghai and the group of non-benzene-exposed workers （X^2=7.95, P〉0.05）. The A type blood distribution frequency in the group of chronic benzene poisoning patients was 42.25%, significantly higher than the group of benzene-exposed workers （29.48%）, and there was statistically significant difference （X^2=5.11 ,P〈0.05）. The B type blood distribution frequency in the group of chronic benzene poisoning patients was 12.68%, significantly lower than the group of benzene-exposed workers （25.15%）, and there was statistically significant difference （X^2=5.61, P〈0.05）. There were no significant differences of the O or AB type blood distribution frequency between the group of chronic benzene poisoning patients and the group of benzene-exposed workers （P〉0.05）. Conclusion The people with A type blood are susceptible to chronic benzene poisoning, however, the people with B type blood are not susceptible to chronic benzene poisoning.