酪氨酸激酶抑制剂耐药机制及其治疗策略
被引量:4
Resistant Mechanism and Treatment Strategy of Tyrosine Kinase Inhibitors
摘要
人类表皮生长因子受体(epidermal growth factor receptor,EGFR)是原癌基因C-erbB1的表达产物,属于酪氨酸激酶生长因子受体家族成员之一,在人类多种实体肿瘤中过度表达,与肿瘤细胞的增殖、侵袭、转移及血管生长等有关。
出处
《中国肺癌杂志》
CAS
2011年第10期806-810,共5页
Chinese Journal of Lung Cancer
参考文献39
-
1O-charoenrat P, Rhys-Evans PH, Archer DJ, et al. C-erbB receptor in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. Oral Oncol, 2002, 38( 1): 73-80.
-
2Koutsopoulos AV, Mavroudis D, Dambaki KI, et al. Simultaneous expression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 receptors in non-small-cell lung carcinomas: correlation with clinical outcome. Lung Cancer, 2007, 57(2): 193-200.
-
3Tiseo M, Rossi G, Capelletti M, et al. Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): study of a comprehensive panel of molecular markers. Lung Cancer, 2010, 67(3): 355-360.
-
4Kim DW, Lee SH, Lee JS, et al. A multicenter phase II study to evaluate the efficacy and safety ofgefitinib as first line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations. Lung Cancer, 2011, 71(1): 65-69.
-
5Shoji F, Yano T, Yoshino I, et al. The characteristics and failure pattern of gefitinib responders with postoperative recurrence of pulmonary adenocarcinoma. EurJ Surg Oncol, 2008, 34(1): 89-93.
-
6Sugio K, Uramoto H, Onitsuka T, et al. Prospective phase II study ofgefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. Lung Cancer, 2009, 64(3): 314-318.
-
7Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N EnglJ Med, 2009, 361 (10): 947-957.
-
8Chen HJ, Mok TS, Chen ZH, et al. Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitor-resistant Chinese non-small cell lung cancer. Pathol Oncol Res, 2009, 15(4): 651-658.
-
9Uramoto H, Shimokawa H, Hanagiri T, et al. Expression of selected gene for acquired resistance to EGFR-TKI in lung adenocarinma. Lung Cancer 2011, 73(3): 361-365.
-
10Taus A, Vollmer I, Arriola E. Activating and resistance mutations of the epidermal growth factor receptor (EGFR) gene and non-small celI lung cancer: a clinical reality. Arch Bronconeumol, 2011, 47(2): 103-105.
二级参考文献32
-
1高霞,刁路明,李恒,夏东,凌长明,刘铭球.非小细胞肺癌中肝细胞生长因子受体蛋白表达及其与肿瘤细胞增殖、血管生成的关系[J].武汉大学学报(医学版),2005,26(3):273-275. 被引量:5
-
2高尚志.我国心胸外科实验研究目前的热点和问题[J].中华实验外科杂志,2006,23(9):1031-1032. 被引量:3
-
3Suzuki M,Shigematsu H,Hiroshima K,et al.Epidermal growth factor receptor expression status in lung cancer correlates with its mutation.Hum Pathol,2005,36:1 127-1 134.
-
4Janmaat M,Rodriguez J,Ruiz M,et al.Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidylinositol-3 kinase pathways in non-small cell lung cancer cells.Int J Cancer,2006,118:209-214.
-
5Maulik G, Shrikhande A, Kijima T, et al. Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and poten tial for therapeutic inhibition [J]. Cytokine Growth Factor Rev, 2002,13(1) :41-59.
-
6RosarioM, BirchmeierW. How tO make tubes: signaling by the Met receptor tyrosine kinase [J]. Trends Cell Biol, 2003,13: 328-35.
-
7Recio JA, Merlino G. Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK/ ATF and cyclinD1 [J]. Oncogene, 2002,21(7):1000-1008.
-
8Paumelle R, Tulasne D, Kherrouche Z, et al. Hepatocyte growth Factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF MEK-ERK signaling pathway [J]. Oncogene, 2002,21 (15) : 2309-2319.
-
9Ichimura E, Maeshima A, Nakajima T, et al. Expression of c- met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance [J]. Jpn J Cancer Res, 1996,87(10):1063-1069.
-
10Siegfried JM, Weissfeld LA, Singh-Kaw P, et al. Association of immunoreaetive hepatocyte growth factor with poor survival in rer, cctable non-small cell lung cancer [J]. Cancer Res, 1997, 57(3) :133-439.
共引文献15
-
1杨帆,陈克终,刘宏伟,隋锡朝,姜冠潮,王俊,李剑锋.K—ras突变导致肺癌细胞对表皮生长因子受体抑制剂耐药的机制[J].中华实验外科杂志,2011,28(8):1232-1234. 被引量:13
-
2卫爱宁,许荣华,庄雅丽,高萍,任梅,王晓华.IGF-1R抑制剂与厄洛替尼对卵巢上皮性癌HO-8910细胞凋亡的影响[J].安徽医科大学学报,2012,47(9):1043-1046. 被引量:4
-
3屈晶晶,顾其华,胡成平.C-MET在非小细胞肺癌对表皮生长因子受体酪氨酸激酶抑制剂耐药中的作用研究进展[J].国际呼吸杂志,2012,32(19):1511-1513.
-
4石丹,冯琼.非小细胞肺癌相关分子标记物的研究进展[J].广东医学,2012,33(22):3503-3505. 被引量:1
-
5冯飞,田辉,岳韦名,李林,李树海,高存,司立博,鲁铭.EGR-1蛋白在人肺鳞状细胞癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2013,20(4):456-460.
-
6张杰.肺癌治疗靶向基因研究进展及临床分子病理检测[J].上海交通大学学报(医学版),2013,33(10):1315-1322. 被引量:3
-
7陈重,魏立,务森,张宁,朱晓明,陈明耀.金属硫蛋白-3表达对A549肺癌株生物学功能的影响[J].中华实验外科杂志,2014,31(10):2200-2203. 被引量:1
-
8邬冬强,杜开齐,张志豪,朱有才,肖怀清,王细勇,陈华飞.肺特异性X蛋白基因在PNO期非小细胞肺癌淋巴结微转移中的表达及临床意义[J].中华实验外科杂志,2014,31(11):2592-2595.
-
9李娟,吕国栋,赵军,肖云峰,王建.胰岛素样生长因子-Ⅰ受体(IGF-ⅠR)抑制剂的研究进展[J].新疆医科大学学报,2014,37(12):1666-1668. 被引量:2
-
10蒙燕,陈樟树.人表皮生长因子受体家族及其抑制剂在临床肿瘤治疗中的应用[J].福建医药杂志,2015,37(1):119-121. 被引量:2
同被引文献55
-
1曾益新.主编.肿瘤学.3版[M].北京:人民卫生出版社,2012:623-636.
-
2胡联民,蔡凯.鼻咽癌治疗的研究进展[J].医学信息,2012.25(6):379-380.
-
3张为远,吴玉梅,主编.官颈病变与官颈癌[M].北京:人民卫生出版社,2012:255-256.
-
4Hackel PO, Zwick E, Prenzel N, et al. Epidermal growth factor reeeptors:eritieal mediators of multiple receptor pathways[J]. Curr Opin Cell Biol, 1999,11 (2) : 184-189.
-
5Dewdney A, Cunningham D, Tabernero J, et al. Multicenter randomized phase Ⅱ clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C)[J]. J Clin Oncol, 2012, 30(14) : 1620-1627.
-
6Sun PL, Li B, Ye QF. Effect of neoaajuvant cetuximab, capecitabine,and radiotherapy for locally advanced rectal cancer: results of a phase Ⅱ study[J].IntJ Coloreetal Dis, 2012,27(10): 1325-1332.
-
7Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for loco regionally advanced head and neck cancer: 5- year survival data from a phase 3 randomized trial, and relation between cetuximab-induced rash and survival [ J]. I.aneet Oncol, 2010,11(1) :21-28.
-
8Okano S,Yoshino T,Fujii M, et al. Phase Ⅱ study of cetuximab plus concomitant boost radiotherapy in Japanese patients with locally advanced squamous cell carcinoma of the head and neck[J]. Jpn J Clin Oncol,2013,43(5) :476-482.
-
9Chen Y, Wu X, Bu S, et al. Promising outcomes of definitive chemoradiation and cetuximab for patients with esophageal squamouscell carcinoma[J]. Cancer Sci, 2012, 103 (11): 1979- 1984.
-
10Crosby T, Hurt CN, Falk S, et al. Chemoradiotherapy with or without cetuximab in patients with oesophageal cancer (SCOPE1) : a multicentre,phase 2/3 randomized trial[J]. Lancet Oncol, 2013, 14(7) : 627-637.
引证文献4
-
1李辰晨,冯继锋.肺癌表皮生长因子受体酪氨酸激酶抑制剂获得性耐药的逆转[J].国际肿瘤学杂志,2013,40(11):843-846.
-
2江伟,张章,齐志峰,吴越菲,秦岭,刘鹏英,孙玲玲,王仪胜.多西他赛联合铂类治疗晚期非小细胞肺癌临床观察[J].安徽医学,2014,35(9):1223-1225. 被引量:2
-
3阴进兰,孔为民.西妥昔单抗联合放疗在恶性肿瘤治疗中的研究进展[J].中华妇幼临床医学杂志(电子版),2014,10(4):128-130.
-
4邵明莎,马术超,彭祥福,白信法,张少云,姚雷.盐酸d3-Poziotinib的设计合成及体外肝微粒体稳定性研究[J].烟台大学学报(自然科学与工程版),2019,32(3):220-225.
-
1涂小煌.乳腺癌的化疗方案[J].中国临床医生杂志,2011,39(7):9-11. 被引量:4
-
2宋泉毅,张大昕.微RNA与肺癌及人类表皮生长因子受体突变状态的研究进展[J].医学综述,2016,22(4):703-706. 被引量:3
-
3邓明凤,王昌富,郭华雄,陈登峰,黄俊,李滔.乳腺癌患者HER2基因表达状态及临床病理意义探讨[J].中国实验诊断学,2011,15(2):330-332.
-
4周桂台.三阴乳腺癌的临床特点及预后分析[J].中国当代医药,2010,17(31):157-157.
-
5杨顺娥,李迅.雌激素受体β和人类表皮生长因子受体2在乳腺癌中的表达及其临床意义[J].中华肿瘤杂志,2007,29(10):767-768. 被引量:6
-
6舒文斌,曹家庆.HER-2在胃癌研究中的新进展[J].生命科学,2013,25(3):324-328. 被引量:3
-
7王春燕,汤丽娜,祁伟祥,张剑军,郑水儿,姚阳,林峰.HER-2过表达与骨肉瘤预后关系的Meta分析[J].山东医药,2015,55(8):70-72.
-
8任泽华,张一清,李金峰.乳腺浸润性小叶癌与浸润性导管癌比较分析[J].中国药物与临床,2012,12(8):1075-1077. 被引量:5
-
9李森,李治国,成龙,薛英威.H er -2阳性胃癌靶向治疗的研究进展[J].实用肿瘤学杂志,2015,29(2):188-192. 被引量:7
-
10王传省,张芳.三阴性乳腺癌96例临床特征与预后分析[J].肿瘤研究与临床,2013,25(5):350-352. 被引量:10