温度对异氟醚和七氟醚在Oxygent^(TM)中的分配系数的影响

Effect of temperature on the partition coefficient of isoflurane and sevoflurane in perflurocarbon emulsion(Oxygent^(TM))

目的测定异氟醚和七氟醚在氟碳化合物乳剂OxygentTM中的分配系数,评价分配系数与温度之间的关系,并比较异氟醚和七氟醚不同温度条件下的分配系数。方法采用注射器-锥形瓶二次顶空平衡法,利用气相色谱仪测定一个大气压下,4、22、27、32℃及37℃五个温度条件下,异氟醚和七氟醚在OxygentTM中的分配系数,分析分配系数与温度的相关性。结果一个大气压,4、22、27、32℃和37℃温度时,异氟醚为85.30±5.60,40.48±1.09,37.14±3.64,27.38±2.28和24.66±1.03;七氟醚在OxygentTM中的分配系数分别为91.54±5.40,42.50±0.91,37.21±2.76,25.43±1.03和28.05±1.74。异氟醚和七氟醚分配系数和温度的线性回归方程分别为:Y=-1.893X+89.20(R2=0.942);Y=-2.075X+95.58(R2=0.951)。两个分配系数均与温度呈显著性相关。在4、22℃以及37℃条件下,七氟醚在OxygentTM中的分配系数高于异氟醚(P<0.05)。结论随着温度升高,异氟醚和七氟醚在OxygentTM中的分配系数逐渐下降。七氟醚在OxygentTM中的溶解性高于异氟醚。

Objective To investigate the effect of temperature on the partition coefficient of isoflurane and sevoflurane in perflurocarbonate emulsion（OxygentTM）.Methods The partition coefficients of isoflurane and sevoflurane in perflurocarbonate emulsion（OxygentTM） were measured at different temperatures（4,22,27,32 and 37 ℃） using syringe-flask double headspace equilibration technique with gas chromatography,and the relationship between the partition coefficients and the temperature was analyzed.Results At 4,22,27,32 and 37 ℃,the partition coefficients of isoflurane in OxygentTM were 85.30±5.60,40.48±1.09,37.14±3.64,27.38±2.28 and 24.66±1.03,and those of sevoflurane were 91.54±5.40,42.50±0.91,37.21±2.76,25.43±1.03 and 28.05±1.74,respectively.The partition coefficients of sevoflurane at 4,22 and 37 ℃ were significantly higher than those of isoflurane（P0.05）.The regression equations between the partition coefficient and temperature for isoflurane and sevoflurane were Y=-1.893X＋89.20（R2=0.942） and Y=-2.075X＋95.58（R2=0.951）,respectively.An inverse linear relationship was found between temperature and the partition coefficient.Conclusion Within a specified range of temperatures,the partition coefficients isoflurane and sevoflurane decrease as the temperature increases.Sevoflurane shows a high solubility in OxygentTM as compared to isoflurane.