双膦酸盐类药物研究及应用进展

Research and application progress of bisphosphonates

双膦酸盐是一种广泛应用于医药领域的人工合成化合物,由于该类物质具有良好的趋骨性和高效的抑制骨吸收的功能,一直是药物化学工作者研究的热点。本文系统综述了近年来双膦酸盐类抗骨吸收药物的发展概况、构效关系、作用机理及应用方面的研究进展。

Bisphosphonates are very useful synthetic compounds in the field of medicine. Because of their good bone affinity and highly efficient inhibition of bone resorption, the research of bisphosphonates has been a hot topic for chemical and pharmaceutical workers. This paper systematically reviews the current research progress in the development of bone resorption inhibitive bisphosphonates, relationship between structure and activity, mechanism of action, and the application.