蒙古沙土鼠不同幽门螺杆菌菌株感染相关性胃病的研究进展

Gastric diseases in Mongolian gerbils infected with different strains of Helicobacter pylori

幽门螺杆菌(Helicobacter pylori,H.pylori)感染在世界范围内高发,他定植于人胃黏膜,导致慢性胃炎及胃癌的发生.蒙古沙鼠(mongolian gerbil,MG)很少患自发性胃炎,且不是H.pylori的自然宿主.人工接种H.pylori后,蒙古沙鼠患H.pylori相关性胃病与胃病患者最相似,是一个公认的人类胃病的动物模型.采用不同H.pylori菌株感染蒙古沙鼠,经常会导致不同的H.pylori相关性胃病的发生,其原因可能与H.pylori致病菌株密切有关.因此,明确H.pylori的致病菌株及其机制,可以为筛选H.pylori致病菌株提供理论参考,并有利于对H.pylori相关性胃病患者进行个体化治疗.本文对蒙古沙土鼠不同H.pylori菌株感染相关性胃疾病研究进展进行综述.

Helicobacter pylori （H.pylori） is a bacterium responsible for one of the most widespread infections found in humans. It colonizes the gastric mucosa and can result in chronic gastritis and gastric cancer. The incidence of spontaneous gastric gastritis is low in Mongolian gerbils, and spontaneous H.pylori infection can not be detected in this animal. Since H.pylori-related gastric diseases in Mongolian gerbils are very similar to those in humans, they have been considered as ideal animals to establish H.pylori infection models. However, different strains of H.pylori may induce different types of pathologic changes in Mongolian gerbils. Clarification of the pathogenic mechanisms of different strains of H.pylori may provide a theoretical basis for screening appropriate H.pylori strains and directing individualized treatment in patients with H.pylori-related gastric diseases. In this paper, we review the recent progress in research of gastric diseases in Mongolian gerbils infected with different strains of H.pylori.