慢性前列腺炎与细胞因子的关系研究进展

Chronic prostatitis and cytokines

慢性前列腺炎(CP)是男科常见病,其发病机制至今尚未明确。CP的不同类型、发展过程中的不同阶段都伴随着细胞因子水平的精细调节,炎症、炎症细胞与细胞因子交互作用促进了CP的发生发展。随着对CP发病机制的免疫学及分子生物学研究不断深入,更多的炎性细胞因子应用于CP的检测过程中,运用细胞因子检测手段对CP进行合理分型,并制定相应的治疗方法,尤为重要。本文就细胞因子在前列腺炎尤其是慢性非细菌性前列腺炎(CAP)或慢性盆腔疼痛综合征(CPPS)的发病中所起的作用,与CP的关系及其在CP/CPPS的分型、诊断中的意义进行综述。

Chronic prostatitis（CP） is a common disease in men,and its pathogenesis remains to be clarified.The precise regulation of cytokines is involved in all types and all stages of CP.The interaction of inflammation,inflammatory cells and cytokines leads to the development and progression of CP.With further understanding of the immunological and molecular biological mechanisms of the disease and more inflammatory cytokines used in its detection,it is of special significance to apply cytokines in the classification and treatment of CP.This review outlines the roles of cytokines in the pathogenesis of CP,particularly chronic pelvic pain syndrome（CPPS）,their relationship with CP,and their significance in the classification and diagnosis of CP/CPPS.