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布鲁菌通过干扰自噬途径实现免疫逃逸 被引量：3

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摘要 布鲁菌病是一种人畜共患传染病，其致病菌属于兼性厌氧胞内寄生菌。人类因接触病畜产品而感染。布鲁菌通过黏膜进入机体，并扩散到网状内皮系统及其他组织（肝、脾、淋巴结及骨关节等）长期定居、繁殖、产毒致病。患者表现为波浪热，少数还并发关节和骨的炎症…。布鲁菌这种长期的“定居”行为，显示其能够突破机体免疫防御系统，具有强大的生存和致病能力。因此，深入探讨布鲁菌逃避免疫系统的识别和清除机制，对于治疗、预防和控制布鲁菌病有一定意义。
作者 孟明 洪洋 李春晓 周蕾 陈冬志
机构地区 河北大学医学部保定
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2011年第9期854-856,共3页 Chinese Journal of Microbiology and Immunology
关键词 布鲁菌病 免疫逃逸 人畜共患传染病 自噬 干扰 网状内皮系统 免疫防御系统 致病能力
分类号 R516.7 [医药卫生—内科学]
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参考文献35

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同被引文献43

  • 1葛丽敏,王光旭.食源性布鲁氏菌病[J].中国地方病防治,2007,22(3):227-228. 被引量：20
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中华微生物学和免疫学杂志
2011年 第9期

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