昆明地区儿童幽门螺杆菌感染状况及危险因素分析

The status and risk factors of Helicobacter pylori infection in children in Kunming

目的了解和探讨昆明地区儿童幽门螺杆菌感染状况及其危险因素。方法随机抽取2008年1月至2010年6月在儿科就诊无消化道症状并做血清H.pylori抗体检测的儿童进行问卷调查。通过单因素配对资料χ2分析及多因素logistic回归分析,筛选出危险因素。结果共478例儿童中H.pylori IgG阳性238例,感染率为49.8%。其中1～3岁、4～7岁、8～14岁H.pylori IgG阳性率分别为24.3%、42.4%、58.3%。学龄期儿童(>7岁)占总感染人数的64.7%。而年龄、共用牙刷口杯、共用餐具、家庭人口数多、经济收入低、人均居住面积小及父母亲和照顾者有胃病史等为H.pylori感染的危险因素。结论 H.pylori感染在儿童中,尤其学龄儿童较为常见,与年龄相关。H.pylori感染危险因素的筛查为预防提供指导。

Objective To explore the status and risk factors of Helicobacter pylori（H.pylori）infection in children in Kunming.Methods Four hundred and seventy-eight children without gastrointestinal trouble admitted in pediatrics were randomly recruited.Serum IgG antibodies to H.pylori were measured.A structured questionnaire was sent to the parents of these children to obtain related information.The risk factors were analysed using univariate factor analysis and unconditional logistic regression analysis.Results Two hundred and thirty-nine（49.8%）children were H.pylori IgG positive.The positive rate of H.pylori IgG was 24.3% in 1 ～ 3 years old,42.4% in 4 ～ 7 years old,and 58.3% in 8 ～ 14 years old,which was 64.7% in school-age children（ 7 years old）.Age,sharing toothbrush,sharing utensils,large families,low income,small per capita living area,and parents or caregivers with a history of stomach disease were the high risk factors for H.pylori infection.Conclusions Infection of H.pylori is common in children,especially in school-age children.Screening the risk factors of H.pylori infection will help to prevention.