恶性骨肿瘤新血管形成机制研究进展

Progress in the study on mechanisms of malignant primary bone tumor neovascularization

骨肉瘤、Ewingps肉瘤和软骨肉瘤等恶性骨肿瘤多为高度血管化肿瘤,严重危害青少年患者,病死率高。虽然包括手术和化疗在内的综合治疗改善了这些患者的预后,但相当一部分患者还是很快发生转移,而这正是主要的死因。恶性骨肿瘤具有多种维持和增加血供的机制,因而使得肿瘤生长及转移。本文就有关恶性骨肿瘤新血管形成的分子生物学机制方面的研究进展作一综述。

Osteosarcoma,Ewing＇s sarcoma and chondrosarcoma are highly vascular tumors that cause a large amount of cancer-related death in children and young adults.An integrated treatment that combines chemotherapy and wide tumor excision has markedly improved the prognosis for these patients.However,pulmonary metastasis,the major cause of death,still occurs in a considerable amount of cases after the treatment.There are multiple mechanisms by which malignant bone tumors develop and maintain their vascular supply.These mechanisms allow tumors to continue to grow in size and metastasize.In this paper,the progress of molecular biological mechanisms of malignant primary bone tumors has been reviewed.