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β-干扰素对SD大鼠急性脊髓损伤后Bax、Fas、Bcl-2基因表达的影响 被引量：1

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摘要 目的研究β-干扰素在SD大鼠急性脊髓损伤中的治疗作用,探讨其对凋亡基因Bax、Fas、Bcl-2的表达的影响。方法用Allen装置撞击SD大鼠脊髓胸9-10(T9-10)节段,建立脊髓损伤模型。术后分为A组-脊髓损伤组(SCI组),B组-甲泼尼龙琥珀酸钠组(MP组),C组-β-干扰素组(IFN-β),D组(假手术组),用反转录聚合酶链式反应(RT-PCR)法检测各组损伤脊髓组织中Bax、Fas、Bcl-2的基因表达情况。结果 RT-PCR结果显示:甲泼尼龙琥珀酸钠及β-干扰素能明显降低Bax、Fas表达,升高Bcl-2表达。结论β-干扰素具有减少SD大鼠急性脊髓损伤后Bax、Fas表达,并促使抑制Bcl-2表达。
作者 林院 吴世强 徐杰 周仕国 罗奋棋
机构地区 福建医科大学省立临床医学院骨科 福建医科大学第二临床学院骨科
出处 《福建医药杂志》 CAS 2011年第5期70-72,共3页 Fujian Medical Journal
关键词 Β-干扰素 脊髓损伤 BAX FAS Bcl-2 凋亡相关基因
分类号 R651.2 [医药卫生—外科学]
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共引文献6

同被引文献22

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福建医药杂志
2011年 第5期

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