P53、Ki67在宫颈癌中表达及意义的探讨(附83例分析)

Expression of P53 and Ki67 in human cervical carcinoma and its clinical significance

目的探讨P53、Ki67在宫颈癌中的表达及临床意义。方法应用免疫组化S-P法对83例宫颈癌组织进行P53和Ki67的检测,并通过统计学方法分析其与临床病理因素间的关系。结果 P53和Ki67在宫颈癌组织中阳性表达率分别为61.45%、75.90%,两者的阳性表达呈正相关关系(r=0.23,P<0.05);P53、Ki67的表达与宫颈癌的病理分级、淋巴结转移有关(P<0.05),与患者年龄、肿瘤直径、临床分期无关(P>0.05)。结论 P53和Ki67的表达与宫颈癌的转移密切相关,两者的联合检测,对宫颈癌的预后评估具有参考价值。

Objective To investigate the expression of P53 and Ki67 in cervical carcinomas and its clinical significance. Methods S-P immunohistochemical technique was used to detect the expression of P53 and Ki67 in 83 cases of cervical carcinoma tissue. Correlation between the expression of P53 and Ki67, and the clinical features and pathological features were statistically analyzed at the same time. Results The positive expression rates of P53 and Ki67 in cervical carcinoma tissue were 61.45% and 75.90%, and there was a closely positive correlation between P53 and Ki67 （P〈0. 05）. The expression of P53 and Ki67 was significantly correlated with pathtogical grade and lymoph node metastasis （P〈0.05）, but not correlated with ages, tumor volume and clinical stage （P〉0.05）. Conclusion The results of the experiment suggest that the expression of P53 and Ki67 was closely related with tumor metastasis, which means that the combined detection of P53 and Ki67 could be used to estimate the prognosis in cervical carcinoma.