腺苷蛋氨酸治疗慢性乙型肝炎疗效观察

Clinical curative effect of S-Adenosylmethionine in treating chronic hepatitis B with hyperbilirubinemia

目的观察腺苷蛋氨酸治疗胆红素升高的慢性乙型肝炎的疗效。方法对120例胆红素升高的慢性乙型肝炎患者资料进行回顾性分析。观察组60例在甘草酸类保肝药物治疗基础上加用腺苷蛋氨酸治疗,对照组60例仅接受甘草酸类药物治疗,疗程2周,分别观察治疗前后血清TBiL、DBiL、ALT、AST、γ-GT、ALP的变化。结果两组经治疗后血清TBiL、DBiL、ALT、AST均有下降,观察组γ-GT、ALP亦有下降;观察组TBiL、DBiL、ALT、AST、γ-GT、ALP下降幅度均大于对照组。结论腺苷蛋氨酸能促进肝功能指标复常,是治疗胆红素升高的慢性乙型肝炎的良好药物。

Objective To observe the clinical curative effect of S-Adenosylmethionine （SAMe） in treating chronic hepatitis B with hyperbilirubinemia. Methods To retrospectively analyse 120 cases of chronic hepatitis B patients with hyperbilirubinemia. Sixty cases treated with both glycyrrhizin therapy and SAMe were considered as the treatment group while the other 60 eases treated with only glyeyrrhizin therapy as the control group. Serum TBiL, DBiL, ALT, AST, γ-GT and ALP were observed and compared before and two weeks after the treatments. Results After treatments, significant declines in the levels of serum TBiL DBiL ALT and AST were observed in both groups, and also in γ-GT and ALP in the treatment group. The levels of TBiL DBiL ALT AST γ-GT and ALP dropped more in the treatment group than control group. Conclusion SAMe can improve liver function and is a good treatment for chronic hepatitis B with hyperbilirubinemia.