肿瘤干细胞生长相关的信号转导通路

Growth Signaling Pathways of Cancer Stem Cells

肿瘤干细胞是肿瘤中存在的一小群具有自我更新和分化潜能的细胞,也是存在于肿瘤组织中具有干细胞样能力的肿瘤细胞亚群,在肿瘤的发生、发展中起着非常重要的作用.近年来发现,肿瘤干细胞的生长调控与Wnt、Notch、Hedgehog等多种信号转导通路有关.本文简要综述了肿瘤干细胞生长相关信号转导通路的研究进展,旨在为肿瘤干细胞研究和临床应用提供理论依据.

Cancer stem cells（CSCs） are the small population of cells involved in tumor possessing renewal and differentiation properties,also known as the stem cell-like cell subpopulations in tumors,which play an important role in tumor occurrence and development.Recent discoveries revealed that the growth regulation of tumor cells was significantly related to the Notch,Wnt and Hedgehog signaling pathways,etc..To provide a theoretical basis for CSCs research and clinical application,we briefly reviewed the research advancements of the signal transduction pathways related to CSCs growth.